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Test ID NMHIN N-Methylhistamine, 24 Hour, Urine

Useful For

Screening for and monitoring of mastocytosis and disorders of systemic mast-cell activation, such as anaphylaxis and other forms of severe systemic allergic reactions

 

Monitoring therapeutic progress in conditions that are associated with secondary, localized, low-grade persistent, mast-cell proliferation and activation such as interstitial cystitis

Method Name

NMH: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

NCTU: Enzymatic Colorimetric Assay

Reporting Name

N-Methylhistamine, U

Specimen Type

Urine


Specimen Required


Container/Tube: Plastic, 5-mL tube (T465)

Specimen Volume: 5 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. No preservative.

Additional Information:

1. 24-Hour volume is required.

2. 24-Hour collection is preferred, but random specimen is also acceptable.

3. See Urine Preservatives in Special Instructions for multiple collections.


Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 8 days
  Frozen  14 days
  Ambient  24 hours

Reference Values

0-5 years: 120-510 mcg/g creatinine

6-16 years: 70-330 mcg/g creatinine

>16 years: 30-200 mcg/g creatinine

Day(s) and Time(s) Performed

Tuesday, Thursday; 10 a.m.

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information

82542

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NMHIN N-Methylhistamine, U In Process

 

Result ID Test Result Name Result LOINC Value
NCTU_ Creatinine Conc 2161-8
21589 N-Methylhistamine, U 44340-8
TM73 Collection Duration 13362-9
VL63 Urine Volume 3167-4

Test Classification

This test was developed and its performance characteristics determined by Laboratory Medicine and Pathology, Mayo Clinic. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Profile Information

Test ID Reporting Name Available Separately Always Performed
NMH N-Methylhistamine, U No Yes
NCTU Creatinine Concentration No Yes

Urine Preservative Collection Options

Ambient

Yes

Refrigerated

Preferred

Frozen

Yes

6N HCl

Yes

50% Acetic Acid

Yes

Na2CO3

Yes

Toluene

Yes

6N HNO3

Yes

Boric Acid

Yes

Thymol

Yes