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Test ID OPATX Opiates Confirmation, Chain of Custody, Urine

Useful For

Detection and quantification of codeine, hydrocodone, oxycodone, morphine, hydromorphone, oxymorphone, noroxycodone, noroxymorphone, norhydrocodone, dihydrocodeine, and naloxone in urine

 

Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was under the control of personnel involved with testing the specimen at all times; this control implies that the opportunity for specimen tampering would be limited.

Method Name

Immunoassay Followed by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Confirmation with Quantitation

Reporting Name

Opiate Confirmation, CoC, U

Specimen Type

Urine


Specimen Required


Specimen Type: Urine

Container/Tube: Chain-of-Custody Kit (T282) containing the specimen containers, seals, and documentation required.

Specimen Volume: 20 mL

Collection Instructions: Collect specimen in the container provided, seal, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing. 

Additional Information

1. If urine creatinine is required or adulteration of the sample is suspected, the following test should be requested, ADLTX / Adulterants Survey, Chain of Custody, Urine. For additional information, please refer to ADLTX / Adulterants Survey, Chain of Custody, Urine.

2. Submitting <20 mL will compromise our ability to perform all necessary testing.


Specimen Minimum Volume

2.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reference Values

Negative

Cutoff concentrations

 

IMMUNOASSAY SCREEN

300 ng/mL

 

Codeine by LC-MS/MS: 25 ng/mL

Dihydrocodeine-by LC-MS/MS: 25 ng/mL

Hydrocodone by LC-MS/MS: 25 ng/mL-

Norhydrocodone-by LC-MS/MS: 25 ng/mL

Hydromorphone by LC-MS/MS: 25 ng/mL

Oxycodone by LC-MS/MS: 25 ng/mL

Noroxycodone-by LC-MS/MS: 25 ng/mL

Oxymorphone by LC-MS/MS: 25 ng/mL

Noroxymorphone-by LC-MS/MS: 25 ng/mL

Naloxone-by LC-MS/MS: 25 ng/mL

Morphine by LC-MS/MS: 25 ng/mL

Day(s) and Time(s) Performed

Monday through Friday

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information

80361

80365

G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OPATX Opiate Confirmation, CoC, U In Process

 

Result ID Test Result Name Result LOINC Value
6541 Opiates Immunoassay Screen 19295-5
36213 Codeine-by LC-MS/MS 16250-3
42005 Dihydrocodeine-by LC-MS/MS 19448-0
36214 Hydrocodone-by LC-MS/MS 16252-9
42006 Norhydrocodone-by LC-MS/MS 78868-7
36215 Hydromorphone-by LC-MS/MS 16998-7
36216 Oxycodone-by LC-MS/MS 16249-5
42007 Noroxycodone-by LC-MS/MS 77779-7
36212 Oxymorphone-by LC-MS/MS 17395-5
42008 Noroxymorphone-by LC-MS/MS No LOINC Needed
42009 Naloxone-by LC-MS/MS 77207-9
36217 Morphine-by LC-MS/MS 16251-1
36218 Opiates Interpretation 69050-3
36219 Chain of Custody No LOINC Needed

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Testing Algorithm

Adulterants testing will be performed on all chain of custody urine samples as per regulatory requirements.

Additional Tests

Test ID Reporting Name Available Separately Always Performed
COCH Chain of Custody Processing No Yes
ADLTX Adulterants Survey, CoC, U Yes Yes