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Test ID TREC T-Cell Receptor Excision Circles (TREC) Analysis, Blood

Useful For

Measuring T-cell output or reconstitution (thymopoiesis) following hematopoietic cell transplantation or highly active antiretroviral therapy

 

Evaluating thymic function in patients with cellular or combined primary immunodeficiencies, or receiving immunotherapy or cancer vaccines

 

Assessing T-cell recovery following thymus transplants for DiGeorge syndrome

Special Instructions

Method Name

Real-Time Quantitative Polymerase Chain Reaction (PCR)

Reporting Name

TREC, B

Specimen Type

Whole Blood EDTA


Specimen Required


This assay is useful for longitudinal assessment of thymic function and naive T-cell production. For comprehensive thymic function analysis on pediatric patients or posthematopoietic cell transplantation, order this test and CD4RT / CD4 T-Cell Recent Thymic Emigrants (RTE).

 

Specimens are required to be received in the laboratory weekdays and by 4 p.m. on Friday. It is recommended that specimens arrive within 24 hours of draw. Specimens arriving on the weekend may be canceled. Draw and package specimen as close to shipping time as possible. Ship specimen overnight in an Ambient Mailer-Critical Specimens Only (T668).

 

Container/Tube: Lavender top (EDTA)

Specimen Volume:

Adults: 10 mL

Pediatrics:

-Preferred volume for >1 year = 5 mL

-Preferred volume for ≤1 year old = 3 mL

Collection Instructions:

1. Do not draw specimen through a butterfly needle.

2. Send specimen in original tube. Do not aliquot.

Additional Information:

1. Ordering physician's name and phone number are required.

2. For serial monitoring, we recommend that specimen draws be performed at the same time of day.

Forms: TREC Assay Patient Information (T589) in Special Instructions


Specimen Minimum Volume

Adults: 10 mL/Pediatrics: 1 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole Blood EDTA Ambient 48 hours

Reference Values

The appropriate age-related reference values will be provided on the report.

Day(s) and Time(s) Performed

Varies

Do not send specimen after Thursday. Specimen must be received by 10 a.m. on Friday.

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information

81479-Unlisted molecular pathology procedure

LOINC Code Information

Test ID Test Order Name Order LOINC Value
TREC TREC, B In Process

 

Result ID Test Result Name Result LOINC Value
28306 CD3 T Cells 8122-4
28307 CD4 T Cells 24467-3
28308 CD8 T Cells 14135-8
87959 TREC Copies In Process
30292 Interpretation 69048-7
35200 Reviewed by No LOINC Needed

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.