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Test ID UGTI UDP-Glucuronosyl Transferase 1A1 (UGT1A1), Full Gene Sequencing, Irinotecan Hypersensitivity

Useful For

Identifying individuals who are at increased risk of adverse drug reactions with drugs that are metabolized by UGT1A1, including irinotecan, atazanavir, nilotinib, pazopanib, and belinostat

Genetics Test Information

This test includes gene sequencing of UGT1A1 and the results are interpreted for the purposes of UGT1A1 drug metabolism. If UGT1A1 gene sequencing is desired for interpretation related to hyperbilirubinemia syndromes including Gilbert syndrome and Crigler-Najjar syndrome, order UGT2 / UDP-Glucuronosyl Transferase 1A1 (UGT1A1), Full Gene Sequencing, Hyperbilirubinemia.

Method Name

Polymerase Chain Reaction (PCR) Followed by Gene Sequencing

Reporting Name

UGT1A1 Gene Sequence, Irinotecan

Specimen Type

Whole Blood EDTA


Specimen Required


Multiple whole blood EDTA genotype tests can be performed on a single specimen after a single extraction. See Multiple Whole Blood EDTA Genotype Tests in Special Instructions for a list of tests that can be ordered together.

 

Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions: Send specimen in original tube.

Forms:

1. New York Clients-Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing (T576) is available in Special Instructions.

2. If not ordering electronically, complete, print, and send an Oncology Test Request Form (T729) with the specimen

(http://www.mayomedicallaboratories.com/it-mmfiles/oncology-request-form.pdf)


Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole Blood EDTA Ambient (preferred)
  Refrigerated 

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Tuesday; Varies

Performing Laboratory

Mayo Medical Laboratories in Rochester

CPT Code Information

81350-UGT1A1 (UDP glucuronosyltransferase 1 family, polypeptide AI) (eg, irinotecan metabolism), gene analysis, common variants (eg, *28, *36, *37)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
UGTI UGT1A1 Gene Sequence, Irinotecan In Process

 

Result ID Test Result Name Result LOINC Value
UGTSQ UGT, Full Gene Sequencing In Process
89397 UGT1A1 Irinotecan Result 34509-0
29339 UGT1A1 Irinotecan Interp 69047-9
29340 Reviewed by No LOINC Needed

Test Classification

See Individual Test IDs

Profile Information

Test ID Reporting Name Available Separately Always Performed
UGT1 UGT1A1 Gene Sequence, Irinotecan No Yes
UGTSQ UGT, Full Gene Sequencing No Yes

Testing Algorithm

See UGT1A1 Test-Ordering Algorithm in Special Instructions.