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Test ID 23BPG 2,3-Dinor-11Beta-Prostaglandin F2 Alpha, Urine

Useful For

Screening for mast cell activation disorders including systemic mastocytosis


2,3-Dinor-11beta-prostaglandin F2 alpha (2,3 BPG) is elevated in the urine of patients with systemic mastocytosis (SM).


2,3 BPG should be used as a screening test for systemic mastocytosis.


When 2,3 BPG is used in combination with urinary leukotriene E4 (LTE4) and N-methyl histamine (NMH), the sensitivity for SM detection increases to 90%.

Testing Algorithm

When this test is performed, urine creatinine will always be performed at no additional charge.

Method Name

23BPG: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

AACT: Enzymatic Colorimetric Assay

Reporting Name

2,3-dinor 11B-Prostaglandin F2a, U

Specimen Type


Advisory Information


Specimen Required

Submit only 1 of the following specimens:


Patient Preparation: Patients taking aspirin or nonsteroidal anti-inflammatory drugs (NSAIDs) may have decreased concentrations of prostaglandin F2 alpha. If possible, discontinue for 2 weeks or 72 hours, respectively, prior to collecting a specimen.


Preferred: 24-hour urine collection

Supplies: Plastic, 5-mL tube (T465)

Specimen Volume: 4 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Refrigerate specimen during collection, and send specimen refrigerated.

Additional Information:

See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.


Acceptable: Random collection

Supplies: Plastic, 5-mL tube (T465)

Specimen Volume: 4 mL

Collection Instructions:

1. Collect a random urine specimen. 

2. Refrigerate specimen after collection. Send specimen refrigerated or frozen; do not add any preservative.

Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 14 days
  Frozen  30 days
  Ambient  8 hours

Reference Values

<5,205 pg/mg creatinine

Day(s) and Time(s) Performed

Monday, Thursday; 11 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
23BPG 2,3-dinor 11B-Prostaglandin F2a, U In Process


Result ID Test Result Name Result LOINC Value
37931 2,3-dinor 11B-Prostaglandin F2a, U In Process

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection.







50% Acetic Acid


Boric Acid


Diazolidinyl Urea


6M Hydrochloric Acid


6M Nitric Acid


Sodium Carbonate