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Test ID 2HGCF 2-Hydroxyglutaric Acid Chiral Analysis, Quantitative, Spinal Fluid


Ordering Guidance


This test is recommended for baseline evaluation or ongoing monitoring of a patient with a suspected or known IDH-mutant tumor.

 

The recommended screening test for the initial workup of a patient with a suspected genetic biochemical disorder of 2-hydroxyglutaric aciduria is OAU / Organic Acids Screen, Random, Urine; followed by 2HGA / 2-Hydroxyglutaric Acid Chiral Analysis, Quantitative, Random, Urine.



Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 0.3 mL

Collection Instructions:

1. Collect cerebrospinal fluid per protocol.

2. Collect specimen for this test in a separate vial.

3. Send in original specimen collection container. Do not aliquot.


Useful For

Evaluating or monitoring cerebrospinal fluid concentrations of 2-hydroxyglutaric acid in individuals with a glioma

Genetics Test Information

Quantitation of the D and L forms of 2-hydroxyglutaric acid in cerebrospinal fluid is useful for management of patients with IDH-mutant tumors.

Method Name

Gas Chromatography-Mass Spectrometry (GC-MS)

Reporting Name

D-,L-2-Hydroxyglutaric Acid, CSF

Specimen Type

CSF

Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Frozen (preferred) 90 days
  Ambient  90 days
  Refrigerated  90 days

Reference Values

D-2-HYDROXYGLUTARIC ACID

≤0.60 nmol/mL

 

L-2-HYDROXYGLUTARIC ACID

≤0.50 nmol/mL

Day(s) Performed

Monday

Report Available

4 to 10 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

83921 x 2

LOINC Code Information

Test ID Test Order Name Order LOINC Value
2HGCF D-,L-2-Hydroxyglutaric Acid, CSF 79294-5

 

Result ID Test Result Name Result LOINC Value
618213 Interpretation 79299-4
618214 D-2-Hydroxyglutaric acid 79304-2
618215 L-2-Hydroxyglutaric acid 79317-4
618216 Reviewed By 18771-6

NY State Approved

Yes