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Test ID ADMPU Addiction Medicine Profile with Reflex, 22 Drug Classes, High Resolution Mass Spectrometry and Immunoassay Screen, Random, Urine


Ordering Guidance


This test does not screen for drug classes other than those listed above.



Specimen Required


Supplies: Urine Container, 60 mL (T313)

Collection Container/Tube: Plastic urine container

Submission Container/Tube: Plastic, 60-mL urine container

Specimen Volume: 30 mL

Collection Instructions:

1. Collect a random urine specimen.

2. Submit 30 mL in 1 plastic bottle.

3. No preservative.

Additional Information:

1. No specimen substitutions.

2. Submitting less than 30 mL may compromise the ability to perform all necessary testing.

3. STATS are not accepted for this procedure.


Useful For

Detecting drug use involving stimulants, barbiturate, benzodiazepines, cocaine, opioids, tetrahydrocannabinol, alcohol, and nicotine

 

This test is not intended for use in employment-related testing.

Profile Information

Test ID Reporting Name Available Separately Always Performed
LPCM List Patient's Current Medications No Yes
ADULT Adulterants Survey, U Yes Yes
PNRCH Drug Immunoassay Panel, U No Yes
TOPSU Targeted Opioid Screen, U Yes, TOSU Yes
TABSU Targeted Benzodiazepine Screen, U Yes, TBSU Yes
TSTIM Targeted Stimulant Screen, U Yes, TSPU Yes
ETGSR Ethyl Glucuronide Scrn w/Reflex, U No Yes
NICOU Nicotine and Metabolites, U Yes Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
COKEU Cocaine and metabolite Conf, U Yes No
BARBU Barbiturates Confirmation, U Yes No
THCU Carboxy-THC Confirmation, U Yes No
ETGC Ethyl Glucuronide Confirmation, U Yes No

Testing Algorithm

Testing begins with an adulterant survey. If the sample is found to be adulterated, testing will end, and the remaining tests will be canceled.

 

If the specimen is normal or only diluted, remaining testing will continue.

 

If immunoassay screen is positive, confirmation testing can be ordered separately. Confirmation with quantification of positives for barbiturates, cocaine and metabolites, tetrahydrocannabinol metabolite, and ethyl glucuronide/ethyl sulfate will be performed at an additional charge.

Method Name

ADULT: Spectrophotometry (SP)

PNRCH: Screened by Immunoassay/Confirmed by Gas Chromatography-Mass Spectrometry (GC-MS)

TOPSU, TABSU, TSTIM: Liquid Chromatography-Tandem Mass Spectrometry, High-Resolution Accurate Mass (LC-MS/MS HRAM)

ETGSR: Screened by Immunoassay/Confirmed by Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

NICOU: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Addiction Med Profile,22,HRMS/IA, U

Specimen Type

Urine

Specimen Minimum Volume

20 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

ADULTERANT SURVEY:

Cutoff concentrations

Oxidants: 200 mg/L

Nitrites: 500 mg/L

 

DRUG IMMUNOASSAY PANEL:

Negative

Screening cutoff concentrations:

Barbiturates: 200 ng/mL

Cocaine (benzoylecgonine-cocaine metabolite): 150 ng/mL

Tetrahydrocannabinol carboxylic acid: 50 ng/mL

This report is intended for use in clinical monitoring or management of patients. It is not intended for use in employment-related testing.

 

TARGETED OPIOID SCREEN:

Not Detected

 

Cutoff concentrations:

Codeine: 25 ng/mL

Codeine-6-beta-glucuronide: 100 ng/mL

Morphine: 25 ng/mL

Morphine-6-beta-glucuronide: 100 ng/mL

6-monoacetylmorphine: 25 ng/mL

Hydrocodone: 25 ng/mL

Norhydrocodone: 25 ng/mL

Dihydrocodeine: 25 ng/mL

Hydromorphone: 25 ng/mL

Hydromorphone-3-beta-glucuronide: 100 ng/mL

Oxycodone: 25 ng/mL

Noroxycodone: 25 ng/mL

Oxymorphone: 25 ng/mL

Oxymorphone-3-beta-glucuronide: 100 ng/mL

Noroxymorphone: 25 ng/mL

Fentanyl: 2 ng/mL

Norfentanyl: 2 ng/mL

Meperidine: 25 ng/mL

Normeperidine: 25 ng/mL

Naloxone: 25 ng/mL

Naloxone-3-beta-glucuronide: 100 ng/mL

Methadone: 25 ng/mL

EDDP: 25 ng/mL

Propoxyphene: 25 ng/mL

Norpropoxyphene: 25 ng/mL

Tramadol: 25 ng/mL

O-desmethyltramadol: 25 ng/mL

Tapentadol: 25 ng/mL

N-desmethyltapentadol: 50 ng/mL

Tapentadol-beta-glucuronide: 100 ng/mL

Buprenorphine: 5 ng/mL

Norbuprenorphine: 5 ng/mL

Norbuprenorphine glucuronide: 20 ng/mL

 

TARGETED BENZODIAZEPINE SCREEN:

Not Detected

 

Cutoff concentrations:

Alprazolam: 10 ng/mL

Alpha-Hydroxyalprazolam: 10 ng/mL

Alpha-Hydroxyalprazolam Glucuronide: 50 ng/mL

Chlordiazepoxide: 10 ng/mL

Clobazam: 10 ng/mL

N-Desmethylclobazam: 200 ng/mL

Clonazepam: 10 ng/mL

7-aminoclonazepam: 10 ng/mL

Diazepam: 10 ng/mL

Nordiazepam: 10 ng/mL

Flunitrazepam: 10 ng/mL

7-aminoflunitrazepam: 10 ng/mL

Flurazepam: 10 ng/mL

2-Hydroxy Ethyl Flurazepam: 10 ng/mL

Lorazepam: 10 ng/mL

Lorazepam Glucuronide: 50 ng/mL

Midazolam: 10 ng/mL

Alpha-Hydroxy Midazolam: 10 ng/mL

Oxazepam: 10 ng/mL

Oxazepam Glucuronide: 50 ng/mL

Prazepam: 10 ng/mL

Temazepam: 10 ng/mL

Temazepam Glucuronide: 50 ng/mL

Triazolam: 10 ng/mL

Alpha-Hydroxy Triazolam: 10 ng/mL

Zolpidem: 10 ng/mL

Zolpidem Phenyl-4-Carboxylic acid: 10 ng/mL

 

TARGETED STIMULANT SCREEN:

Not Detected

 

Cutoff concentrations:

Methamphetamine: 100 ng/mL

Amphetamine: 100 ng/mL

3,4-methylenedioxymethamphetamine (MDMA): 100 ng/mL

3,4-methylenedioxy-N-ethylamphetamine (MDEA): 100 ng/mL

3,4-methylenedioxyamphetamine (MDA): 100 ng/mL

Ephedrine: 100 ng/mL

Pseudoephedrine: 100 ng/mL

Phentermine: 100 ng/mL

Phencyclidine (PCP): 20 ng/mL

Methylphenidate: 20 ng/mL

Ritalinic acid: 100 ng/mL

 

ETHYL GLUCURONIDE SCREEN:

Negative

 

Screening cutoff concentrations:

Ethyl Glucuronide: 500 ng/mL

 

NICOTINE AND METABOLITES:

Non-tobacco user with no passive exposure:

Nicotine: <5.0 ng/mL

Cotinine: <5.0 ng/mL

Anabasine: <2.0 ng/mL

Nornicotine: <2.0 ng/mL

Day(s) Performed

ADULT, PNRCH: Monday through Saturday

TOPSU, TABSU, TSTIM: Monday through Friday

ETGSR: Monday through Sunday

NICOU: Monday through Sunday

Profile tests: Monday through Sunday; Reflex tests: Varies

Report Available

2 to 5 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information

80307

80347

80364

80326

80323

G0482 (if appropriate)

G0483 (if appropriate)

LOINC Code Information

Result ID Test Result Name Result LOINC Value
LPCM List Patient's Current Medications 66423-5
610273 Methamphetamine 19554-5
20606 Creatinine, U 2161-8
82510 Nicotine 3854-7
604871 Alprazolam 94116-1
42323 Codeine 19411-8
2574 Barbiturates 70155-7
616033 Ethyl Glucuronide Screen, U 58375-7
21652 Cocaine 19359-9
42324 Codeine-6-beta-glucuronide 89310-7
604867 Alpha-Hydroxyalprazolam 19325-0
21321 Cotinine 10366-3
22312 Specific Gravity 5810-7
610274 Amphetamine 19343-3
610275 3,4-methylenedioxymethamphetamine (MDMA) 19568-5
23509 pH 2756-5
21324 Nornicotine 33917-6
604891 Alpha-Hydroxyalprazolam Glucuronide 94115-3
42325 Morphine 19597-4
2664 Tetrahydrocannabinol 19415-9
42326 Morphine-6-beta-glucuronide 89308-1
604872 Chlordiazepoxide 19385-4
21323 Anabasine 33915-0
23511 Oxidants 58714-7
610276 3,4-methylenedioxy-N-ethylamphetamine (MDEA) 59844-1
610277 3,4-methylenedioxyamphetamine (MDA) 19565-1
23510 Nitrites 32710-6
604889 Clobazam 94114-6
42327 6-monoacetylmorphine 19321-9
42328 Hydrocodone 19482-9
604890 N-Desmethylclobazam 94113-8
30914 Comment 48767-8
610278 Ephedrine 99108-3
610279 Pseudoephedrine 99109-1
604873 Clonazepam 19399-5
42329 Norhydrocodone 89304-0
42330 Dihydrocodeine 19446-4
604267 7-aminoclonazepam 94112-0
610280 Phentermine 19674-1
610281 Phencyclidine (PCP) 19659-2
604874 Diazepam 19443-1
42331 Hydromorphone 19486-0
42332 Hydromorphone-3-beta-glucuronide 89309-9
604880 Nordiazepam 19624-6
610282 Methylphenidate 19577-6
610283 Ritalinic acid 99110-9
604875 Flunitrazepam 19466-2
42333 Oxycodone 19642-8
42334 Noroxycodone 89303-2
604866 7-aminoflunitrazepam 94111-2
610284 Stimulant Interpretation 54247-2
604876 Flurazepam 19474-6
42335 Oxymorphone 19646-9
42336 Oxymorphone-3-beta-glucuronide 89301-6
604868 2-Hydroxy Ethyl Flurazepam 94110-4
604877 Lorazepam 19520-6
42337 Noroxymorphone 89302-4
42338 Fentanyl 59673-4
604878 Lorazepam Glucuronide 94109-6
604879 Midazolam 19585-9
42339 Norfentanyl 43199-9
42340 Meperidine 19532-1
604869 Alpha-Hydroxy Midazolam 94108-8
604881 Oxazepam 19638-6
42341 Normeperidine 27920-8
42342 Naloxone 42618-9
604882 Oxazepam Glucuronide 94107-0
604883 Prazepam 19678-2
42343 Naloxone-3-beta-glucuronide 89307-3
42344 Methadone 19550-3
604884 Temazepam 19698-0
604885 Temazepam Glucuronide 94106-2
42345 EDDP 93495-0
42346 Propoxyphene 19429-0
604886 Triazolam 19714-5
604870 Alpha-Hydroxy Triazolam 94105-4
42347 Norpropoxyphene 19632-9
42348 Tramadol 19710-3
604887 Zolpidem 94104-7
604888 Zolpidem Phenyl-4-Carboxylic acid 94103-9
42349 O-desmethyltramadol 86453-8
42350 Tapentadol 72485-6
604949 Benzodiazepine Interpretation 69050-3
42351 N-desmethyltapentadol 89306-5
42352 Tapentadol-beta-glucuronide 89300-8
42353 Buprenorphine 93494-3
42354 Norbuprenorphine 82371-6
42355 Norbuprenorphine glucuronide 89305-7
65059 Opioid Interpretation 69050-3

NY State Approved

Yes