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HelpTest ID APCRR Activated Protein C Resistance V (APCRV), with Reflex to Factor V Leiden, Plasma
Useful For
Evaluation of patients with incident or recurrent venous thromboembolism (VTE)
Evaluation of individuals with a family history of VTE
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| APCRV | Activated Protein Resistance V, P | Yes | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| F5DNA | Factor V Leiden (R506Q) Mutation, B | Yes | No |
| F5DNI | APCRV/F5DNA Summary Interpretation | No | No |
Testing Algorithm
If the assay ratio is abnormal, then R506Q mutation will be performed at an additional charge.
When the activated protein C resistance V is abnormal or indeterminate and R506Q mutation assay is reflexed, then a summary interpretation will be provided.
Special Instructions
Method Name
Optical Clot-Based
Reporting Name
APCRV, w/Reflex, PSpecimen Type
Plasma Na CitWhole blood
Specimen Required
See Coagulation Studies in Special Instructions: Guidelines for Specimen Handling and Processing.
Both blood and plasma are required.
Specimen Type: Whole blood
Container/Tube:
Preferred: Yellow top (ACD)
Acceptable: EDTA or sodium citrate
Specimen Volume: Full tube
Collection Instructions:
1. Invert several times to mix blood.
2. Send specimen in original tube.
Additional Information: Each molecular coagulation test requested must have its own tube.
Specimen Type: Platelet-poor plasma
Patient Preparation: Fasting preferred
Collection Container/Tube: Light-blue top (citrate)
Submission Container/Tube: Polypropylene vial
Specimen Volume: 1 mL
Collection Instructions:
1. Spin down, remove plasma, and spin plasma again.
2. Freeze plasma aliquots immediately (no longer than 4 hours after collection) at -20° C, or, ideally ≤-40 degrees C.
Additional Information:
1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.
2. If priority specimen, mark request form, give reason, and request a call-back.
3. Each coagulation assay requested should have its own vial.
Specimen Minimum Volume
Plasma: 0.5 mL
Whole Blood: 3 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Plasma Na Cit | Frozen | 14 days |
| Whole blood | Ambient (preferred) | 7 days |
| Frozen | 14 days | |
| Refrigerated | 14 days |
Reference Values
APCRV RATIO
≥2.3
Pediatric reference range has neither been established nor is available in scientific literature. The adult reference range likely would be applicable to children older than 6 months.
Day(s) and Time(s) Performed
Monday through Friday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
85307
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| APCRR | APCRV, w/Reflex, P | 13590-5 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| APCR | APCRV Ratio | 13590-5 |
| INT55 | Interpretation | 48591-2 |
Forms
1. New York Clients-Informed consent is required. Please document on the request form or electronic order that a copy is on file. An Informed Consent for Genetic Testing (T576) is available in Special Instructions.
2. Coagulation Patient Information (T675) in Special Instructions
3. If not ordering electronically, complete, print, and send a Coagulation Test Request (T753) with the specimen.