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Test ID APCZ APC Gene, Full Gene Analysis, Varies

Useful For

Confirmation of familial adenomatous polyposis (FAP) diagnosis for patients with clinical features

Additional Tests

Test ID Reporting Name Available Separately Always Performed
COLAB Hereditary Colon Cancer CGH Array Yes, (order FMTT) Yes

Testing Algorithm

When this test is ordered, comparative genomic hybridization will always be performed at an additional charge.

 

See Colonic Polyposis Syndromes Testing Algorithm in Special Instructions.

Method Name

Custom Sequence Capture and Targeted Next-Generation Sequencing

COLAB: Array Comparative Genomic Hybridization (aCGH)

Reporting Name

APC Gene, Full Gene Analysis

Specimen Type

Varies


Ordering Guidance


This test should be ordered only for individuals with symptoms suggestive of familial adenomatous polyposis (FAP). Asymptomatic patients with a family history of FAP should not be tested until a variant has been identified in an affected family member.



Shipping Instructions


Specimen preferred to arrive within 96 hours of collection.



Specimen Required


Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.

Specimen Type: Whole blood

Container/Tube:

Preferred: Lavender top (EDTA) or yellow top (ACD)

Acceptable: Any anticoagulant

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.


Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)
  Frozen 
  Refrigerated 

Reference Values

An interpretive report will be provided.

Day(s) Performed

Varies

Report Available

14 to 20 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81201

Hereditary Colon Cancer CGH Array, additional test

81228

LOINC Code Information

Test ID Test Order Name Order LOINC Value
APCZ APC Gene, Full Gene Analysis 94188-0

 

Result ID Test Result Name Result LOINC Value
53568 Result Summary 50397-9
53569 Result 82939-0
53570 Interpretation 69047-9
53571 Additional Information 48767-8
53572 Specimen 31208-2
53573 Source 31208-2
53574 Array Billed? No LOINC Needed
53575 Released By 18771-6

NY State Approved

Yes

Forms

1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available in Special Instructions:

-Informed Consent for Genetic Testing (T576)

-Informed Consent for Genetic Testing-Spanish (T826)

2. Molecular Genetics: Inherited Cancer Syndromes Patient Information (T519) in Special Instructions

3. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Oncology Test Request (T729)

-Gastroenterology and Hepatology Client Test Request (T728)

Highlights

APC gene sequence analysis for 5' UTR and exons 1 through 15.

 

Array comparative genomic hybridization (aCGH) is used to test for the presence of large deletions and duplications encompassing the coding regions as well as promoter 1A and 1B of the APC gene.