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Test ID APGAL Galactose-Alpha-1,3-Galactose (Alpha-Gal) Mammalian Meat Allergy Profile, Serum


Advisory Information


For a listing of allergens available for testing, see Allergens - Immunoglobulin E (IgE) Antibodies in Special Instructions



Specimen Required


Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1.5 mL


Useful For

As an aid in diagnosis of an IgE mediated hypersensitivity allergy to non-primate mammalian red meat or meat-derived products, such as beef, pork, venison, and meat-derived products such as gelatin via allergen profile testing

 

This test is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists.

 

This test is not useful for patients in whom the medical management does not depend upon identification of allergen specificity.

Highlights

The presence of IgE antibodies against galactose-alpha-1,3-galactose (alpha-gal) is associated with red meat allergy.

 

Individuals with IgE antibodies against alpha-gal might develop anaphylactic reactions to the drug cetuximab.

Profile Information

Test ID Reporting Name Available Separately Always Performed
ALGAL Galactose-alpha-1,3-galactose, IgE Yes Yes
BEEF Beef, IgE Yes Yes
PORK Pork, IgE Yes Yes
LAMB Lamb, IgE Yes Yes
MILK Milk, IgE Yes Yes

Testing Algorithm

Other meat allergen IgE antibody tests may be considered in addition to galactose-alpha-1,3-galactose IgE antibody testing in cases of suspected red meat allergy.

Method Name

Fluorescence Enzyme Immunoassay (FEIA)

Reporting Name

Alpha-Gal Panel, S

Specimen Type

Serum

Specimen Minimum Volume

For 1 allergen: 0.3 mL
For more than 1 allergen: (0.05 mL x number of allergens) + 0.25 mL deadspace

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  90 days

Reference Values

Galactose-Alpha-1,3-Galactose:

Class

IgE kU/L

Interpretation

0

<0.10

Negative

0/1

0.10-0.34

Borderline/equivocal

1

0.35-0.69

Equivocal

2

0.70-3.49

Positive

3

3.50-17.4

Positive

4

17.5-49.9

Strongly positive

5

50.0-99.9

Strongly positive

6

≥100

Strongly positive

Concentrations ≥0.70 Ku/L (Class 2 and above) will flag as abnormally high


For BEEF, PORK, LAMB, MILK:

Class

IgE kUa/L

Interpretation

0

<0.35

Negative

1

0.35-0.69

Equivocal

2

0.70-3.49

Positive

3

3.50-17.4

Positive

4

17.5-49.9

Strongly positive

5

50.0-99.9

Strongly positive

6

≥100

Strongly positive

Reference values apply to all ages.

Day(s) and Time(s) Performed

Monday through Friday; 9 a.m.-8 p.m.

Saturday; 8 a.m.-3 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved or is exempt by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86003 x 5

LOINC Code Information

Test ID Test Order Name Order LOINC Value
APGAL Alpha-Gal Panel, S In Process

 

Result ID Test Result Name Result LOINC Value
BEEF Beef, IgE 6039-2
LAMB Lamb, IgE 6155-6
MILK Milk, IgE 6174-7
PORK Pork, IgE 6219-0
ALGAL Galactose-alpha-1,3-galactose, IgE 73837-7

NY State Approved

Yes