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Test ID ATTI Antithrombin Antigen, Plasma

Useful For

Assessing abnormal results of the antithrombin activity assay (ATTF / Antithrombin Activity, Plasma), which is recommended as the primary (screening) antithrombin assay

 

Diagnosing antithrombin deficiency, acquired or congenital, in conjunction with measurement of antithrombin activity

 

An adjunct in the diagnosis and management of carbohydrate-deficient glycoprotein syndromes

Method Name

Latex Immunoassay (LIA)

Reporting Name

Antithrombin Antigen, P

Specimen Type

Plasma Na Cit


Ordering Guidance


Antithrombin activity (ATTF / Antithrombin Activity, Plasma) is usually used for monitoring treatment of antithrombin deficiency disorders, including infusion of antithrombin therapeutic concentrate.



Necessary Information


If patient is being treated with heparin, this should be noted as heparin treatment may lower plasma antithrombin.



Specimen Required


See Coagulation Guidelines for Specimen Handling and Processing in Special Instructions.

 

Patient Preparation: Fasting preferred

Collection Container/Tube: Light-blue top (citrate)

Submission Container/Tube: Polypropylene vial

Specimen Volume: 1 mL

Collection Instructions:

1. Centrifuge, remove plasma, and centrifuge plasma again.

2. Freeze plasma immediately (no longer than 4 hours after collection) at -20° C or, ideally, ≤-40° C.

Additional Information:

1. Double-centrifuged specimen is critical for accurate results as platelet contamination may cause spurious results.

2. Each coagulation assay requested should have its own vial.


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma Na Cit Frozen 14 days

Reference Values

Adults: 80-120%

Normal, full-term newborn infants may have decreased levels (≥35-40%), which reach adult levels by 180 days postnatal.*

Healthy, premature infants (30-36 weeks gestation) may have decreased levels, which reach adult levels by 180 days postnatal.*

*See Pediatric Hemostasis References section in Coagulation Guidelines for Specimen Handling and Processing in Special Instructions.

Day(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

85301

LOINC Code Information

Test ID Test Order Name Order LOINC Value
ATTI Antithrombin Antigen, P 27812-7

 

Result ID Test Result Name Result LOINC Value
ATTI Antithrombin Antigen, P 27812-7

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Report Available

Same day/1 to 4 days

NY State Approved

Yes