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Test ID CATU Catecholamine Fractionation, Free, 24 Hour, Urine

Useful For

An auxiliary test to fractionated plasma and urine metanephrine measurements in the diagnosis of pheochromocytoma and paraganglioma

 

An auxiliary test to urine vanillylmandelic acid and homovanillic acid determination in the diagnosis and follow-up of patients with neuroblastoma and related tumors

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Catecholamine Fract, Free, U

Specimen Type

Urine


Ordering Guidance


This assay is of greatest value when the specimen is collected during a hypertensive episode.

 

Do not perform the test on patients withdrawing from legal or illegal drugs known to cause rebound catecholamine release during withdrawal (see Cautions for details)

 

This test should not be used as the first-line test for pheochromocytoma. The recommended first-line laboratory tests for pheochromocytoma are PMET / Metanephrines, Fractionated, Free, Plasma and/or METAF / Metanephrines, Fractionated, 24 Hour, Urine.



Necessary Information


24-Hour volume is required.



Specimen Required


Patient Preparation:

1. Discontinue drugs that release or hinder metabolism of epinephrine, norepinephrine, or dopamine for at least 1 week before specimen collection (see Cautions for details). If this is not possible for medical reasons, contact the laboratory to discuss whether a shorter drug-withdrawal period may be acceptable.

2. Unless the reason for testing is drug monitoring, discontinue any epinephrine, norepinephrine, or dopamine injections or infusions for at least 12 hours before specimen collection.

Supplies: Plastic, 10-mL urine tube (T068)

Specimen Volume: 2 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Add 25 mL of 50% acetic acid as preservative at start of collection. Use 15 mL of 50% acetic acid for children less than 5 years old. This preservative is intended to achieve a pH of between approximately 2 and 4.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.


Specimen Minimum Volume

1.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 7 days
  Frozen  14 days
  Ambient  7 days

Reference Values

NOREPINEPHRINE

 <1 year: <11 mcg/24 hours

1 year: 1-17 mcg/24 hours

2-3 years: 4-29 mcg/24 hours

4-6 years: 8-45 mcg/24 hours

7-9 years: 13-65 mcg/24 hours

≥10 years: 15-80 mcg/24 hours

 

EPINEPHRINE

 <1 year: <2.6 mcg/24 hours

1 year: <3.6 mcg/24 hours

2-3 years: <6.1 mcg/24 hours

4-9 years: 0.2-10.0 mcg/24 hours

10-15 years: 0.5-20.0 mcg/24 hours

≥16 years: <21 mcg/24 hours

 

DOPAMINE

<1 year: <86 mcg/24 hours

1 year: 10-140 mcg/24 hours

2-3 years: 40-260 mcg/24 hours

≥4 years: 65-400 mcg/24 hours

 

For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html

Day(s) Performed

Monday through Saturday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82384

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CATU Catecholamine Fract, Free, U 92938-0

 

Result ID Test Result Name Result LOINC Value
TM48 Collection Duration 13362-9
VL46 Urine Volume 3167-4
2106 Norepinephrine 2668-2
2107 Epinephrine 2232-7
2108 Dopamine 2218-6

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Report Available

2 to 4 days

NY State Approved

Yes

Urine Preservative Collection Options

Ambient

No

Refrigerate

OK

Frozen

OK

50% Acetic Acid

Preferred

Boric Acid

OK

Diazolidinyl Urea

No

6M Hydrochloric Acid

OK

6M Nitric Acid

OK

Sodium Carbonate

No

Thymol

No

Toluene

No

Forms

If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.