Test ID CDCOM Celiac Disease Comprehensive Cascade, Serum and Whole Blood
Useful For
Evaluating patients suspected of having celiac disease, including patients with compatible symptoms, patients with atypical symptoms, and individuals at increased risk (family history, previous diagnosis with associated disease)
Comprehensive algorithmic evaluation including HLA typing
Special Instructions
Method Name
IGA: Nephelometry
CELI2: Polymerase Chain Reaction (PCR)/Sequence-Specific Oligonucleotide Probe (SSO)
Reporting Name
Celiac Disease Comprehensive CascSpecimen Type
SerumWhole Blood ACD-B
Advisory Information
This cascade should not be used in patients who have previously been or are currently being treated with a gluten-free diet. For these individuals, CDGF / Celiac Disease Gluten-Free Cascade should be ordered.
This cascade should not be used in patients for whom HLA DQ2/DQ8 typing has already been performed. For individuals who are positive for either DQ2 and/or DQ8, CDSP / Celiac Disease Serology Cascade should be ordered to assess the levels of autoantibodies associated with celiac disease. For individuals who are negative for DQ2 and DQ8, no further testing is necessary as a diagnosis of celiac disease is unlikely.
-CDCOM / Celiac Disease Comprehensive Cascade: complete testing including HLA DQ
-CDSP / Celiac Disease Serology Cascade: complete testing excluding HLA DQ
-CDGF / Celiac Disease Gluten-Free Cascade: for patients already adhering to a gluten-free diet
To order individual tests, see Celiac Disease Diagnostic Testing Algorithm in Special Instructions.
Specimen Required
Both blood and serum are required.
Specimen Type: Blood
Container/Tube: Yellow top (ACD [solution B])
Specimen Volume: 6 mL
Collection Instructions: Do not transfer blood to other containers.
Specimen Type: Serum
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 2 mL
Specimen Minimum Volume
Blood: 3 mL
Serum: 1.5 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Serum | Refrigerated (preferred) | 14 days | |
Frozen | 21 days | ||
Whole Blood ACD-B | Refrigerated (preferred) | ||
Ambient |
Reference Values
IMMUNOGLOBULIN A (IgA)
0-<5 months: 7-37 mg/dL
5-<9 months: 16-50 mg/dL
9-<15 months: 27-66 mg/dL
15-<24 months: 36-79 mg/dL
2-<4 years: 27-246 mg/dL
4-<7 years: 29-256 mg/dL
7-<10 years: 34-274 mg/dL
10-<13 years: 42-295 mg/dL
13-<16 years: 52-319 mg/dL
16-<18 years: 60-337 mg/dL
≥18 years: 61-356 mg/dL
HLA-DQ TYPING
Presence of DQ2 or DQ8 alleles associated with celiac disease
Day(s) and Time(s) Performed
IgA, tTG IgA, Gliadin IgA, tTG IgG, Gliadin IgG: Monday through Saturday; 3 p.m.
HLA-DQ Typing: Monday through Friday; 7:30 a.m.-5 p.m.
Endomysial antibodies: Monday through Friday; 7 a.m.-5 p.m.
Performing Laboratory

CPT Code Information
82784
81376 x 2
83516-Deamidated gliadin IgA (if appropriate)
83516-Deamidated gliadin IgG (if appropriate)
83516-tTG IgA (if appropriate)
83516-tTG IgG (if appropriate)
86255-Endomysial antibodies (if appropriate)
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
CDCOM | Celiac Disease Comprehensive Casc | 94493-4 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
IGA | Immunoglobulin A (IgA), S | 2458-8 |
DQA | DQ alpha 1 | 94495-9 |
28991 | Celiac Disease Interpretation | 69048-7 |
DQB | DQ beta 1 | 53938-7 |
CELIG | Celiac gene pairs present? | 48767-8 |
Test Classification
See Individual Test IDsProfile Information
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
IGA | Immunoglobulin A (IgA), S | Yes | Yes |
CELI2 | HLA-DQ Typing | Yes, (Order CELI) | Yes |
CDCM1 | Celiac Disease Interpretation | No | Yes |
Reflex Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
EMA | Endomysial Abs, S (IgA) | Yes | No |
DAGL | Gliadin(Deamidated) Ab, IgA, S | Yes | No |
TTGG | Tissue Transglutaminase Ab, IgG, S | Yes | No |
DGGL | Gliadin(Deamidated) Ab, IgG, S | Yes | No |
TTGA | Tissue Transglutaminase Ab, IgA, S | Yes | No |
Testing Algorithm
If IgA is age-specified normal, then tissue transglutaminase (tTG) IgA will be performed at an additional charge.
If tTG IgA is equivocal, then endomysial antibodies IgA and deamidated gliadin antibody IgA will be performed at an additional charge.
If IgA is greater than or equal to 1.0 mg/dL but lower than age-specified normal, then tTG IgA, tTG IgG, deamidated gliadin IgA, and deamidated gliadin IgG will be performed at an additional charge.
If IgA is below detection (<1.0 mg/dL), then tTG IgG and deamidated gliadin IgG will be performed at an additional charge.
The following algorithms are available in Special Instructions:
-Celiac Disease Comprehensive Cascade
-Celiac Disease Diagnostic Testing Algorithm
-Celiac Disease Gluten-Free Cascade
NY State Approved
YesForms
If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Client Test Request (T728) with the specimen.