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Test ID CMAH Chromosomal Microarray, Hematologic Disorders, Varies

Useful For

Detection and characterization of clonal copy number imbalance and loss of heterozygosity associated with hematologic neoplasms

 

Assisting in the diagnosis and classification of certain hematologic neoplasms

 

Evaluating the prognosis for patients with certain hematologic neoplasms

Testing Algorithm

DNA extraction is always performed on the specimen prior to hybridization to the microarray. An unstimulated cell culture will be set up on all specimens with adequate volume and held pending additional testing. If additional testing is requested, such as karyotype analysis or FISH, it will be performed at an additional charge.

 

This test is not appropriate for detecting constitutional/congenital copy number changes or regions of excessive homozygosity. If this test is ordered with a reason for referral indicating a constitutional/congenital disorder, the test will be cancelled and CMACB / Chromosomal Microarray, Congenital, Blood will be performed as the appropriate test.

 

The following algorithms are available in Special Instructions:

-Aggressive B-cell Lymphoma Diagnostic Algorithm in Special Instructions

-B-Lymphoblastic Leukemia/Lymphoma Algorithm

Method Name

Chromosomal Microarray (CMA) Using Applied Biosystems (Affymetrix) Cytoscan HD

Reporting Name

Chromosomal Microarray, Hematologic

Specimen Type

Varies


Necessary Information


1. A reason for referral must be provided for testing to be performed.

2. A pathology report should accompany the specimen. If this information is not available at the time of order, submit as soon as possible for appropriateness of testing and to aid in interpretation of results.



Specimen Required


Provide a reason for referral with each specimen. The laboratory will not reject testing if this information is not provided, but appropriate testing and interpretation may be compromised or delayed.

 

Submit only 1 of the following specimens:

 

Specimen Type: Bone marrow
Container/Tube: Green top (sodium heparin)
Specimen Volume: 1-2 mL
Collection Instructions:
1. Invert several times to mix bone marrow.
2. If sodium heparin is not available, EDTA is acceptable.

 

Specimen Type: Whole blood
Container/Tube: Green top (sodium heparin)
Specimen Volume: 7-10 mL
Collection Instructions:
1. Invert several times to mix blood.
2. If sodium heparin is not available, EDTA is acceptable.


Specimen Minimum Volume

Blood: 2 mL
Bone Marrow: 1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)
  Refrigerated 

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Specimens are processed Monday through Sunday.

Results reported Monday through Friday, 8 a.m.-5 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81277

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CMAH Chromosomal Microarray, Hematologic 94087-4

 

Result ID Test Result Name Result LOINC Value
54721 Result Summary 50397-9
54722 Result 62356-1
54723 Nomenclature 62378-5
54724 Interpretation 69965-2
CG902 Reason For Referral 42349-1
CG903 Specimen 31208-2
54725 Source 31208-2
54726 Method 49549-9
53423 Additional Information 48767-8
54727 Released By 18771-6

NY State Approved

Yes

Forms

If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.