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Test ID CORAB Hepatitis B Core Total Antibodies, with Reflex to Hepatitis B Core Antibody IgM, Serum

Useful For

Detection and differentiation between recent and past/resolved or chronic hepatitis B viral (HBV) infection


Diagnosis of recent HBV infection during the "window period" when both hepatitis B surface antigen (HBsAg) and antibodies to HBsAg are negative


This test is not useful for determining immunity to or recovery from hepatitis B viral (HBV) infection.

Special Instructions

Method Name

Chemiluminescence Immunoassay

Reporting Name

HBc Total Ab, w/Reflex, S

Specimen Type

Serum SST

Necessary Information

Date of draw is required.

Specimen Required

Patient Preparation: For 24 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

Collection Container/Tube: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial within 24 hours.

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum SST Frozen (preferred) 28 days
  Refrigerated  7 days
  Ambient  24 hours

Reference Values


Interpretation depends on clinical setting.

See Viral Hepatitis Serologic Profiles in Special Instructions.

Day(s) Performed

Monday through Saturday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information


86705 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
CORAB HBc Total Ab, w/Reflex, S 13952-7


Result ID Test Result Name Result LOINC Value
CORAB HBc Total Ab, w/Reflex, S 13952-7

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HBIM HBc IgM Ab, S Yes No

Testing Algorithm

If hepatitis B core (HBc) total antibodies is positive, then HBc IgM is performed at an additional charge.

Report Available

1 to 3 days

NY State Approved



If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Client Test Request (T728) with the specimen.