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Test ID CRCOF Chromium and Cobalt, Synovial Fluid

Advisory Information

This test should only be used in individuals with chromium or cobalt implants.

Specimen Required

Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for at least 96 hours

Supplies: Metal Free B-D Tube (EDTA), 6 mL (T183)

Container/Tube: Royal blue top (metal-free EDTA)

Specimen Volume: 1 mL

Collection Instructions: See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Additional Information: Cobalt and chromium are present in the black rubber plunger seals found in most disposable syringes. As a result, synovial fluid should not be collected in these devices as contamination may occur.

Useful For

Monitoring metallic prosthetic implant wear and local tissue destruction in failed hip arthroplasty constructs


This test is not useful for assessment of vitamin B12 activity.

Profile Information

Test ID Reporting Name Available Separately Always Performed
CRSY Chromium, Synovial Fl Yes Yes
COSY Cobalt, Synovial Fl Yes Yes

Method Name

Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Reporting Name

Chromium and Cobalt, Synovial Fl

Specimen Type

Synovial Fluid

Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Synovial Fluid Refrigerated (preferred) 90 days
  Ambient  90 days
  Frozen  90 days

Reference Values


0-17 years: Not established

≥18 years: <17.1 ng/mL



0-17 years: Not established

≥18 years: <17.2 ng/mL

Day(s) and Time(s) Performed

Thursday; 8 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information



LOINC Code Information

Test ID Test Order Name Order LOINC Value
CRCOF Chromium and Cobalt, Synovial Fl 95525-2


Result ID Test Result Name Result LOINC Value
606352 Cobalt, Synovial Fl 23842-8
606353 Chromium, Synovial Fl 95526-0

NY State Approved