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Test ID CTX Beta-CrossLaps, Serum

Useful For

Monitoring antiresorptive therapies (eg, bisphosphonates and hormone replacement therapy) in postmenopausal women treated for osteoporosis and individuals diagnosed with osteopenia


An adjunct in the diagnosis of medical conditions associated with increased bone turnover

Method Name

Electrochemiluminescence Immunoassay (ECLIA)

Reporting Name

Beta-CrossLaps (B-CTx), S

Specimen Type


Specimen Required

Patient Preparation:

1. For 12 hours before specimen collection do not take multivitamins or dietary supplements containing biotin (vitamin B7), which is commonly found in hair, skin, and nail supplements and multivitamins.

2. Patient should be fasting.

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube:

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial, 5 mL

Specimen Volume: 1 mL

Collection Instructions:

1. Collect specimen prior to 10 a.m.

2. Centrifuge and aliquot serum into plastic vial.

Specimen Minimum Volume

0.75 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 90 days
  Refrigerated  72 hours

Reference Values


<5 years: 242-1292 pg/mL

5-9 years: 351-1532 pg/mL

10-15 years: 447-2457 pg/mL

16-17 years: 478-1666 pg/mL

18-29 years: 238-1019 pg/mL

30-39 years: 225-936 pg/mL

40-49 years: 182-801 pg/mL

50-59 years: 161-737 pg/mL

60-69 years: 132-752 pg/mL

≥70 years: 118-776 pg/mL



<5 years: 347-1508 pg/mL

5-9 years: 383-1556 pg/mL

10-15 years: 311-1776 pg/mL

16-17 years: 146-1266 pg/mL

18-29 years: 148-967 pg/mL

30-39 years: 150-635 pg/mL

40-49 years: 131-670 pg/mL

50-59 years: 183-1060 pg/mL

60-69 years: 171-970 pg/mL

≥70 years: 152-858 pg/mL

Premenopausal: 136-689 pg/mL

Postmenopausal: 177-1015 pg/mL

Day(s) Performed

Monday through Saturday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
CTX Beta-CrossLaps (B-CTx), S 41171-0


Result ID Test Result Name Result LOINC Value
CTX Beta-CrossLaps (B-CTx), S 41171-0

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Report Available

1 to 3 days

NY State Approved