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Test ID DENGC Dengue Virus, Molecular Detection, PCR, Spinal Fluid


Advisory Information


The presence of dengue virus nucleic acid in cerebrospinal fluid (CSF) or serum (as detected by molecular assays [This test or DENGS / Dengue Virus, Molecular Detection, PCR, Serum] overlaps with the presence of dengue virus nonstructural protein 1 (NS1) antigen (DNSAG / Dengue Virus NS1 Antigen, Serum). Patients with a history of symptoms for more than 1 week may be negative by molecular tests (ie, real-time PCR) and may require serologic testing (DENVP / Dengue Virus Antibody/Antigen Panel, Serum) to confirm the diagnosis of dengue virus infection.



Specimen Required


Supplies: Aliquot Tube, 5 mL (T465)

Preferred: 12 x 75-mm screw cap vial

Acceptable: Sterile screw cap vial

Container/Tube: Sterile vial

Specimen Volume: 0.5 mL

Collection Instructions: Do not centrifuge.


Useful For

Aiding in the diagnosis of central nervous system infection caused by dengue virus

Highlights

Detection of dengue virus nucleic acid in cerebrospinal fluid (CSF) is suggestive of recent exposure or acute central nervous system infection with dengue virus.

 

The presence of dengue virus nucleic acid in CSF or serum can be used as a marker for acute-phase infection.

 

Patients with a history of symptoms for more than 1 week may be negative by molecular tests (ie, real-time PCR) and may require serologic testing to confirm the diagnosis of dengue virus infection.

Testing Algorithm

See Mosquito-borne Disease Laboratory Testing in Special Instructions.

Method Name

Real-Time Polymerase Chain Reaction (PCR)

Reporting Name

Dengue Virus, PCR, CSF

Specimen Type

CSF

Specimen Minimum Volume

0.3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 7 days
  Frozen  7 days

Reference Values

Negative

Day(s) and Time(s) Performed

Tuesday, Thursday; 2 pm.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

87798

LOINC Code Information

Test ID Test Order Name Order LOINC Value
DENGC Dengue Virus, PCR, CSF 94426-4

 

Result ID Test Result Name Result LOINC Value
606371 Dengue Virus, PCR, CSF 94426-4

NY State Approved

Yes