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Test ID FFES Estradiol Free, Serum (includes Estradiol and SHBG)

Method Name

High-pressure liquid chromatography/tandem mass spectrometry (HPLC/MS-MS);Electrochemiluminescence immunoassay (ECLIA)

Reporting Name

Free Estradiol with SHBG

Specimen Type

Serum Red


Specimen Required


Draw blood in a plain red-top tube (serum gel tube is not acceptable). Spin down, pour off into plastic vial within 1 hour of collection, and send 3 mL serum frozen.


Specimen Minimum Volume

1.5 mL Note: This volume does not allow for repeat testing.

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Red Frozen (preferred) 180 days
  Ambient  48 hours
  Refrigerated  48 hours

Reference Values

Estradiol, Serum MS

Units: pg/mL

 

       Age                       Range

Newborn

Levels are markedly elevated at birth and fall rapidly during the first week to prepubertal values of <15.

 

Males <6 m

Levels increase to 10 - 32 between 30 and 60 days, then decline to prepubertal levels of <15 by six months.

 

Females <1 y

Levels increase to 5.0 - 50 between 30 and 60 days, then decline to prepubertal levels of <15 during the first year.

 

Prepubertal                   <15

Adult Males                   8.0 - 35

Adult Females

 Follicular                      30 - 100

 Luteal                          70 - 300

 Postmenopausal          <15

 

Free Estradiol, Percent

Units: %

 

      Age                        Range

Adult Males                 1.7 - 5.4

Adult Females             1.6 - 3.6

 

Free Estradiol, Serum

Units: pg/mL

 

      Age                        Range

Adult Males                 0.2 - 1.5

Adult Females             0.6 - 7.1

 

Sex Hormone Binding Globulin

Units: nmol/L

 

      Age                                    Range

 Infants (1 - 23m)                  60.0 - 252.0

Prepubertal                          72.0 - 220.0

Pubertal

  Males                               16.0 - 100.0

  Females                            36.0 - 125.0

Adult Males

   20 - 49 y                           16.5 - 55.9

   >49y                                 19.3 - 76.4

Adult Females

   20 – 49y                            24.6 - 122.0

   >49y                                 17.3 - 125.0

 

Day(s) and Time(s) Performed

Varies

Performing Laboratory

Esoterix Endocrinology

CPT Code Information

82670 - Estradiol

84270 - Sex Hormone binding globulin

84999 - Unlisted chemistry procedure

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FFES Free Estradiol with SHBG Not Provided

 

Result ID Test Result Name Result LOINC Value
Z0259 Estradiol, Serum 35384-7
Z0228 Free Estradiol, Percent 14960-9
Z0229 Free Estradiol, Serum 2240-0
Z0230 Sex Hormone Binding Globulin (SHBG) 13967-5

Test Classification

This test was developed and its performance characteristics determined by LabCorp. It has not been cleared or approved by the Food and Drug Administration.

NY State Approved

Yes