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Test ID FYABS Yo Antibody Screen with Reflex to Titer and Western Blot

Method Name

Immunofluorescence Assay (IFA)

Western Blot (WB)

Reporting Name

Yo Ab Scr. w/Reflex to Titer and WB

Specimen Type


Specimen Required

Draw blood in a plain red-top tube(s), serum gel tube(s) is acceptable. Spin down and send 0.5 mL of serum ambient in a plastic vial.


Note: Overnight fasting is preferred.

Specimen Minimum Volume

0.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Ambient (preferred) 7 days
  Frozen  21 days
  Refrigerated  14 days

Reference Values

Yo Ab, IFA:       Negative


Purkinje cells cytoplasmic antibody (Yo) can be found in approximately 50% of patients with paraneoplastic cerebellar degeneration (PCD). The presence of Yo antibody strongly suggests underlying gynecological cancer primarily of ovarian or breast origin. A negative assay for Yo antibody does not exclude the possibility of a malignant tumor.

Day(s) Performed

Monday, Wednesday, Friday

Performing Laboratory

Quest Diagnostics Nichols Institute

CPT Code Information

86255 – Screen

84181 – Western Blot with interpretation and report (if appropriate)

86256 – Titer, each antibody (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
FYABS Yo Ab Scr. w/Reflex to Titer and WB 14249-7


Result ID Test Result Name Result LOINC Value
Z3692 Yo Ab, IFA 14249-7

Test Classification

This test was developed and its performance characteristics have been determined by Quest Diagnostics Nichols Institute, San Juan Capistrano. It has not been cleared or approved by the U.S. Food and Drug Administration. The FDA has determined that such clearance or approval is not necessary. Performance characteristics refer to the analytical performance of the test.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
FYABW Yo Ab, Western Blot No No
FYABT Yo Ab Titer No No

Testing Algorithm

If Yo Antibody Screen, IFA is positive, Yo Ab, Western Blot, FYABW, will be performed at an additional charge.

If Yo Antibody, Western Blot is positive, Yo Ab Titer, FYABT, will be performed at an additional charge.

Report Available

4 to 12 days

NY State Approved