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Test ID HCVSP Hepatitis C Virus (HCV) Antibody Screen Prenatal, Serum

Ordering Guidance

This test is intended for testing either symptomatic or asymptomatic women who are pregnant.


For testing autopsy/cadaver or hemolyzed specimens, order HCCAD / Hepatitis C Virus Antibody Screen for Cadaveric or Hemolyzed Specimens, Asymptomatic, Serum for asymptomatic individuals or HCCDD / Hepatitis C Virus Antibody in Cadaveric or Hemolyzed Specimens, Symptomatic, Serum for symptomatic individuals.


Specimens that are repeatedly reactive by screening tests should be confirmed by a more hepatitis C virus (HCV)-specific test. Order HCVRP / Hepatitis C Virus (HCV) RNA Detection and Quantification by Real-Time Reverse Transcription-PCR (RT-PCR), Prenatal.

Shipping Instructions

If shipment will be delayed for more than 24 hours, freeze serum at -70° C until shipment on dry ice.

Necessary Information

Date of collection is required

Specimen Required

Supplies: Aliquot Tube, 5 mL (T465)

Collection Container/Tube: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Collection Instructions:

1. Centrifuge blood collection tube per collection tube manufacturer's instructions (eg, centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes).

2. Aliquot serum into plastic vial.

Useful For

Screening of pregnant women for hepatitis C in primary care settings, with or without risk factors for hepatitis C 

This test should not be used as a screening test for hepatitis C in blood or human cells/tissue donors.


This test profile is not useful for detection or diagnosis of acute hepatitis C virus (HCV), since HCV antibodies may not be detectable until after 2 months following exposure and HCV RNA testing is not performed on specimens with negative HCV antibody screening test results.


This test is intended for screening all women who are pregnant for hepatitis C during each pregnancy and to report positive results to the applicable local communicable disease surveillance agencies.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
HCVRP HCV RNA Detect/Quant Prenatal, S Yes No

Testing Algorithm

If the hepatitis C virus (HCV) antibody screen is reactive, then HCV RNA testing by reverse transcription-polymerase chain reaction (RT-PCR) will be performed at an additional charge.


See Hepatitis C: Testing Algorithm for Screening and Diagnosis in Special Instructions.

Method Name

Chemiluminescence Immunoassay (CIA)

Reporting Name

HCV Ab Scrn Prenatal, S

Specimen Type

Serum SST

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum SST Frozen (preferred) 28 days
  Refrigerated  5 days

Reference Values


See Viral Hepatitis Serologic Profiles in Special Instructions.

Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 2 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


G0472 (if appropriate)

87522 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HCVSP HCV Ab Scrn Prenatal, S 40726-2


Result ID Test Result Name Result LOINC Value
HCVA6 HCV Ab Prenatal, S 40726-2

NY State Approved