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Test ID HCYSP Homocysteine, Total, Plasma

Useful For

An aid for screening patients suspected of having an inherited disorder of methionine metabolism including:

-Cystathionine beta-synthase deficiency (homocystinuria)

-Methylenetetrahydrofolate reductase deficiency (MTHFR) and its thermolabile variants

-Methionine synthase deficiency

-Cobalamin (Cbl) metabolism

-Combined methyl-Cbl and adenosyl-Cbl deficiencies: Cbl C2, Cbl D2, and Cbl F3 deficiencies

-Methyl-Cbl specific deficiencies: Cbl D-Var1, Cbl E, and Cbl G deficiencies

-Transcobalamin II deficiency

-Adenosylhomocysteinase (AHCY) deficiency

-Glycine N-methyltransferase (GNMT) deficiency

-Methionine adenosyltransferase (MAT) I/III deficiency

-Screening and monitoring patients suspected of or confirmed with an inherited disorder of methionine metabolism

-Evaluating individuals with suspected deficiency of vitamin B12 or folate.

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Homocysteine, Total, P

Specimen Type

Plasma EDTA


Necessary Information


Biochemical Genetics Patient Information (T602) is recommended, but not required, for suspected cases of inherited disorders of methionine metabolism.



Specimen Required


Collection Container/Tube:

Preferred: Lavender top (EDTA)

Acceptable: Green top (sodium or lithium heparin)

Submission Container/Tube: Plastic vial

Specimen Volume: 1 mL

Collection Instructions:

1. Immediately place specimen on wet ice.

2. Centrifuge and aliquot plasma into plastic vial within 4 hours of collection.

3. If blood cannot be placed on wet ice immediately, centrifuge and aliquot plasma into plastic vial within 1 hour of collection.

4. A refrigerated centrifuge is not required if the above time restrictions are met.


Specimen Minimum Volume

0.10 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Refrigerated (preferred) 28 days
  Frozen  309 days
  Ambient  28 days

Reference Values

Age

Total homocysteine (nmol/mL)

Female

Male

0-11 months

3.1 - 8.3

3.2 - 9.7

12-23 months

3.2 - 8.3

3.3 - 9.6

24-35 months

3.2 - 8.2

3.3 - 9.6

3 years

3.2 - 8.2

3.3 - 9.6

4 years

3.3 - 8.2

3.4 - 9.5

5 years

3.4 - 8.1

3.5 - 9.4

6 years

3.5 - 8.1

3.6 - 9.4

7 years

3.5 - 8.1

3.7 - 9.4

8 years

3.6 - 8.2

3.8 - 9.3

9 years

3.7 - 8.2

3.9 - 9.4

10 years

3.8 - 8.3

4.1 - 9.4

11 years

3.9 - 8.4

4.3 - 9.4

12 years

3.9 - 8.6

4.4 - 9.5

13 years

4.0 - 8.7

4.6 - 9.6

14 years

4.1 - 8.8

4.8 - 9.7

15 years

4.2 - 8.9

5.0 - 9.8

16 years

4.2 - 9.1

5.2 - 9.9

17 years

4.3 - 9.2

5.4 - 10.0

18 years

4.3 - 9.3

5.6 - 10.1

19 years

4.4 - 9.5

5.7 - 10.3

20 years

4.4 - 9.6

5.9 - 10.5

21 years

4.4 - 9.8

6.0 - 10.6

22 years

4.4 - 9.9

6.1 - 10.8

23 years

4.4 - 10.1

6.2 - 11.0

24 years

4.4 - 10.3

6.2 - 11.1

25 years

4.4 - 10.4

6.3 - 11.3

26 years

4.4 - 10.6

6.3 - 11.4

27 years

4.3 - 10.8

6.4 - 11.6

28 years

4.3 - 11.0

6.4 - 11.7

29 years

4.3 - 11.2

6.4 - 11.8

30 years

4.3 - 11.4

6.4 - 11.9

31 years

4.4 - 11.6

6.4 - 12.1

32 years

4.4 - 11.8

6.4 - 12.2

33 years

4.4 - 11.9

6.4 - 12.3

34 years

4.5 - 12.1

6.4 - 12.4

35 years

4.5 - 12.2

6.4 - 12.6

36 years

4.6 - 12.4

6.4 - 12.8

37 years

4.6 - 12.5

6.4 - 12.9

38 years

4.7 - 12.7

6.4 - 13.1

39 years

4.7 - 12.8

6.4 - 13.2

40 years

4.8 - 13.0

6.5 - 13.4

41 years

4.8 - 13.2

6.5 - 13.5

42 years

4.8 - 13.4

6.5 - 13.7

43 years

4.9 - 13.5

6.6 - 13.9

44 years

4.9 - 13.7

6.6 - 14.0

45 years

4.9 - 13.9

6.6 - 14.2

46 years

4.9 - 14.0

6.7 - 14.4

47 years

4.9 - 14.2

6.7 - 14.5

48 years

5.0 - 14.3

6.8 - 14.7

49 years

5.0 - 14.4

6.8 - 14.9

50 years

5.0 - 14.5

6.8 - 15.0

51 years

5.1 - 14.6

6.8 - 15.2

52 years

5.1 - 14.7

6.9 - 15.4

53 years

5.1 - 14.8

6.9 - 15.5

54 years

5.2 - 14.9

6.9 - 15.6

55 years

5.2 - 15.0

6.9 - 15.7

56 years

5.3 - 15.0

6.9 - 15.8

57 years

5.3 - 15.1

6.9 - 15.9

58 years

5.3 - 15.2

6.9 - 16.0

59 years

5.4 - 15.2

6.9 - 16.0

60 years

5.4 - 15.3

6.9 - 16.1

61 years

5.4 - 15.4

7.0 - 16.2

62 years

5.5 - 15.4

7.0 - 16.2

63 years

5.5 - 15.5

7.0 - 16.3

64 years

5.6 - 15.5

7.1 - 16.3

65 years

5.6 - 15.6

7.1 - 16.3

66 years

5.7 - 15.6

7.1 - 16.3

67 years

5.7 - 15.7

7.2 - 16.3

68 years

5.8 - 15.7

7.2 - 16.3

69 years

5.9 - 15.7

7.2 - 16.3

70 years

6.0 - 15.8

7.3 - 16.3

71 years

6.1 - 15.8

7.3 - 16.3

72 years

6.2 - 15.8

7.3 - 16.3

73 years

6.3 - 15.9

7.3 - 16.3

74 years

6.4 - 15.9

7.3 - 16.3

75 years

6.5 - 15.9

7.3 - 16.3

76 years

6.6 - 15.9

7.3 - 16.3

77 years

6.7 - 16.0

7.4 - 16.3

78 years

6.8 - 16.0

7.4 - 16.3

79 years

6.9 - 16.0

7.5 - 16.3

80 years

7.0 - 16.0

7.5 - 16.3

81 years

7.1 - 16.0

7.7 - 16.2

82 years

7.2 - 16.0

7.8 - 16.2

83 years

7.2 - 16.0

7.9 - 16.2

84 years

7.3 - 16.0

8.0 - 16.2

85 years

7.3 - 16.0

8.2 - 16.2

>85 years

7.4 - 16.0

8.3 - 16.2

Day(s) and Time(s) Performed

Tuesday, Friday; 8 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83090

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HCYSP Homocysteine, Total, P 13965-9

 

Result ID Test Result Name Result LOINC Value
80379 Homocysteine, Total, P 13965-9

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

NY State Approved

Yes

Forms

Biochemical Genetics Patient Information (T602) in Special Instructions.