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Test ID HIVPR HIV-1 Genotypic Drug Resistance to Protease and Reverse Transcriptase Inhibitors, Plasma

Ordering Guidance

This test is intended for monitoring known HIV-positive infections. For primary detection of HIV infections, order HVCOP / HIV-1 and HIV-2 Antigen and Antibody Routine Screen, Plasma.

Shipping Instructions

If shipment will be delayed for more than 24 hours, freeze plasma specimen at -70° C (up to 35 days) until shipment on dry ice.

Specimen Required

Collection Container/Tube: Lavender top (EDTA)

Submission Container/Tube: Plastic vial

Specimen Volume: 2.2 mL

Collection Instructions: Centrifuge and transfer plasma into plastic vial per collection tube manufacturer's instructions (eg, centrifuge and aliquot within 2 hours of collection for BD Vacutainer tubes)

Additional Information: Specimens submitted for HIV-1 genotyping should contain 500 copies/mL or more of HIV-1 RNA.

Useful For

Identification of genotypic variants associated with viral resistance to HIV-1 nucleotide reverse-transcriptase inhibitors, non-nucleotide reverse-transcriptase inhibitors, and protease inhibitors


Guiding initiation or change of combination antiretroviral therapy in individuals, including children, living with HIV

Testing Algorithm

See HIV Treatment Monitoring Algorithm in Special Instructions

Special Instructions

Method Name

Reverse Transcription Polymerase Chain Reaction (RT-PCR), followed by DNA Sequencing

Reporting Name

HIV-1 Genotypic PR-RT Resistance, P

Specimen Type

Plasma EDTA

Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Plasma EDTA Frozen (preferred) 35 days ALIQUOT TUBE
  Refrigerated  5 days ALIQUOT TUBE

Reference Values

Not applicable

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been modified from the manufacturer's instructions. Its performance characteristics were determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
HIVPR HIV-1 Genotypic PR-RT Resistance, P 49659-6


Result ID Test Result Name Result LOINC Value
37216 HIV-1 Genotypic PR-RT Drug Resistance, P 34700-5
37263 Nucleos(t)ide RT mutations 45175-7
21411 Abacavir 30287-7
21406 Didanosine 30284-4
37285 Emtricitabine 41402-9
37284 Lamivudine 30283-6
21408 Stavudine 30286-9
21530 Tenofovir 41396-3
21405 Zidovudine 30282-8
37264 Nonnucleoside RT mutations 45176-5
604980 Doravirine 91897-9
21414 Efavirenz 30291-9
31267 Etravirine 52749-9
21410 Nevirapine 30289-3
34917 Rilpivirine 68463-9
21400 Protease Mutations 33630-5
28076 Atazanavir + Ritonavir 49618-2
26784 Darunavir + Ritonavir 49630-7
26733 Fosamprenavir + Ritonavir 51409-1
26734 Indinavir + Ritonavir 49619-0
21532 Lopinavir + Ritonavir 42000-0
21416 Nelfinavir 30294-3
26735 Saquinavir + Ritonavir 49621-6
28201 Tipranavir + Ritonavir 49622-4

NY State Approved


Day(s) Performed


Report Available

2 to 10 days