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Test ID HL57V HLA-B*57:01 Genotype, Pharmacogenomics, Varies


Specimen Required


Multiple whole blood EDTA genotype tests can be performed on a single specimen. See Multiple Whole Blood EDTA Genotype Tests in Special Instructions for a list of tests that can be ordered together.

 

Submit only 1 of the following specimens:

 

Specimen Type: Whole blood

Container/Tube: Lavender top (EDTA)

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

Specimen Stability Information: Ambient (preferred) 9 days/Refrigerated 30 days

 

Specimen Type: Saliva

Supplies: Saliva Swab Collection Kit (T786)

Patient Preparation: Patient should not eat, drink smoke, or chew gum 30 minutes prior to collection.

Container/Tube: Saliva Swab Collection Kit (T786)

Specimen Volume: 1 swab

Collection Instructions: Collect and send specimen per kit instructions.

Specimen Stability Information: Ambient 30 days

 

Specimen Type: DNA

Container/Tube: 2 mL screw top tube

Specimen Volume: 100 mcL (microliters)

Collection Instructions:

1. The preferred volume is 100 mcL at a concentration of 50 ng/mcL.

2. Include concentration and volume on tube.

Specimen Stability Information: Frozen (preferred) 1 year/Ambient/Refrigerated


Forms

1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available in Special Instructions:

-Informed Consent for Genetic Testing (T576)

-Informed Consent for Genetic Testing-Spanish (T826)

2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) form with the specimen.

Useful For

Identifying individuals with an increased risk of hypersensitivity reactions to abacavir, based on the presence of the human leukocyte antigen HLA-B*57:01 allele

 

Identifying individuals taking pazopanib who have an increased risk of elevated alanine aminotransferase (ALT) levels based of the presence of the human leukocyte antigen HLA-B*57:01 allele

Testing Algorithm

See Abacavir Hypersensitivity Testing and Initial Patient Management Algorithm in Special Instructions.

 

For additional information regarding pharmacogenomic genes and their associated drugs, see the Pharmacogenomic Associations Tables in Special Instructions.

Method Name

Qualitative Allele-Specific Real-Time Polymerase Chain Reaction (PCR)

Reporting Name

HLA-B 5701 Genotype, PGx

Specimen Type

Varies

Specimen Minimum Volume

Blood: 0.4 mL
Saliva: 1 swab

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Varies

Reference Values

Negative

An interpretive report will be provided.

Day(s) and Time(s) Performed

Monday, Wednesday through Friday; 9 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81381

LOINC Code Information

Test ID Test Order Name Order LOINC Value
HL57V HLA-B 5701 Genotype, PGx 50956-2

 

Result ID Test Result Name Result LOINC Value
603339 HLA-B 5701 Genotype 50956-2
603340 HLA-B 5701 Phenotype 93308-5
603341 Interpretation 69047-9
603342 Additional Information 48767-8
603343 Method 49549-9
603344 Disclaimer 62364-5
603345 Reviewed by 18771-6

NY State Approved

Yes