Iduronate-2-Sulfatase, Blood - Mayo Clinic Laboratories Rochester

Useful For

Diagnosis of mucopolysaccharidosis II (MPS II, Hunter syndrome) in whole blood specimens

This test is not useful for determining carrier status for MPS II.

Genetics Test Information

This test provides diagnostic testing for individuals with positive newborn screen results or clinical signs and symptoms suspicious for mucopolysaccharidosis type II (MPS II, Hunter syndrome).

Special Instructions

Method Name

Fluorometric Enzyme Assay

Reporting Name

Iduronate-2-sulfatase, B

Specimen Type

Whole blood

Necessary Information

Provide a reason for testing with each specimen.

Specimen Required

Container/Tube:

Preferred: Lavender top (EDTA)

Acceptable: Yellow top (ACD)

Specimen Volume: 2 mL

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type	Temperature	Time	Special Container
Whole blood	Ambient (preferred)	7 days
	Refrigerated	7 days

Reference Values

≥1.5 nmol/hour/mL

Day(s) Performed

Varies

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82657

LOINC Code Information

Test ID	Test Order Name	Order LOINC Value
I2SW	Iduronate-2-sulfatase, B	79462-8

Result ID	Test Result Name	Result LOINC Value
61902	Iduronate-2-sulfatase, B	79462-8
35211	Reviewed By	18771-6
35212	Interpretation (I2SW)	59462-2

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

Report Available

8 to 15 days

NY State Approved

Yes

Forms

1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available in Special Instructions:

-Informed Consent for Genetic Testing (T576)

-Informed Consent for Genetic Testing-Spanish (T826)

2. Biochemical Genetics Patient Information (T602) in Special Instructions.

3. If not ordering electronically, complete, print, and send a Biochemical Genetics Test Request (T798) with the specimen.