Test ID I2SW Iduronate-2-Sulfatase, Whole Blood
Useful For
Diagnosis of mucopolysaccharidosis II (MPS II, Hunter syndrome) in whole blood specimens
This test is not useful for determining carrier status for MPS II.
Genetics Test Information
This test provides diagnostic testing for individuals with positive newborn screen results or clinical signs and symptoms suspicious for mucopolysaccharidosis type II (MPS II, Hunter syndrome).
Special Instructions
Method Name
Fluorometric Enzyme Assay
Reporting Name
Iduronate-2-sulfatase, BSpecimen Type
Whole bloodNecessary Information
Provide a reason for referral with each specimen.
Specimen Required
Collection Container/Tube:
Preferred: Lavender top (EDTA)
Acceptable: Yellow top (ACD)
Specimen Volume: 2 mL
Specimen Minimum Volume
0.5 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Whole blood | Ambient (preferred) | 7 days | |
Refrigerated | 7 days |
Reference Values
≥1.5 nmol/hour/mL
Day(s) and Time(s) Performed
Varies
Performing Laboratory

CPT Code Information
82657
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
I2SW | Iduronate-2-sulfatase, B | 79462-8 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
61902 | Iduronate-2-sulfatase, B | 79462-8 |
35211 | Reviewed By | 18771-6 |
35212 | Interpretation (I2SW) | 59462-2 |
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.NY State Approved
YesForms
1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file. The following documents are available in Special Instructions:
-Informed Consent for Genetic Testing (T576)
-Informed Consent for Genetic Testing-Spanish (T826)
2. Biochemical Genetics Patient Information (T602) in Special Instructions.
3. If not ordering electronically, complete, print, and send an Inborn Errors of Metabolism Test Request (T798) with the specimen.
Testing Algorithm
The following algorithms are available in Special Instructions: