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Test ID KIT8 KIT Exon 8, Mutation Analysis

Useful For

Diagnosis and management of patients with gastrointestinal stromal tumors or other related tumors

 

Identification of a mutation in exon 8 of the KIT gene

Additional Tests

Test ID Reporting Name Available Separately Always Performed
SLIRV Slide Review in MG No, (Bill Only) Yes

Testing Algorithm

This test is performed in conjunction with SLIRV / Slide Review in MG. Additional testing may be performed after review by pathologist. Upon approval from the requesting clinician, PATHC / Pathology Consultation may be added, if determined to be appropriate.

Special Instructions

Method Name

Polymerase Chain Reaction (PCR) and Sequencing

Reporting Name

KIT exon 8, Mutation Analysis

Specimen Type

Varies


Advisory Information


Special stains performed outside Mayo Clinic Laboratories and included with the case may be repeated and charged at the reviewing pathologist's discretion. Testing requested by referring physician may not be performed if deemed unnecessary by Mayo Clinic pathologist.



Necessary Information


A pathology/diagnostic report including a brief history is required. If available, include KIT Immunostain results.



Specimen Required


A quality specimen is essential for evaluation. Submit only tissue containing tumor cells; minimal tissue is required for evaluation.

 

Supplies: Surgical Pathology Packaging Kit (T554) requested, but not required

 

Preferred:

Specimen Type: Formalin fixed, paraffin-embedded (FFPE) tissue block with a minimum of 60% tumor cell population

Collection Instructions: Process all specimens into FFPE tissue blocks prior to submission.

 

Acceptable:

Specimen Type: Unstained slides with a minimum of 60% tumor population; slides may be stained and/or scraped

Slides: A minimum of ten, 4- to 5-micron thick, unstained slides are required.


Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)
  Frozen 
  Refrigerated 

Reference Values

An interpretative report will be provided.

Day(s) and Time(s) Performed

Monday through Friday; Varies

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information

81272-KIT (v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog) (eg, gastrointestinal stromal tumor [GIST], acute myeloid leukemia, melanoma), gene analysis, targeted sequence analysis (eg, exons 8, 11, 13, 17, 18)

88381-Microdissection, manual

LOINC Code Information

Test ID Test Order Name Order LOINC Value
KIT8 KIT exon 8, Mutation Analysis 87733-2

 

Result ID Test Result Name Result LOINC Value
54790 Result Summary 50397-9
54791 Result 82939-0
54792 Interpretation 69047-9
54793 Additional Information 48767-8
54794 Reason for Referral 42349-1
54795 Specimen 31208-2
54796 Source 31208-2
54797 Tissue ID 80398-1
54798 Released By 18771-6

NY State Approved

Yes

Forms

1. Pathology/Cytology Information (T707) in Special Instructions

2. If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:

-Pathology Test Request (T246)

-Oncology Test Request (T729)