Test ID LUNGR Lung Cancer Rearrangement Testing, Tumor
Useful For
Identifying lung tumors that may respond to targeted therapies by simultaneously assessing multiple genes involved in rearrangements resulting in fusion transcripts
Diagnosis and management of patients with lung cancer
Genetics Test Information
This test uses next-generation sequencing to identify rearrangements (fusions) involving ALK, ROS1, RET, and NTRK1. See Activated/Partner Gene Breakpoints Resulting in Targeted Fusion Transcripts Interrogated by Lung Panel in Special Instructions for details regarding the targeted gene regions evaluated by this test.
Of note, this test is performed to evaluate rearrangements (fusions) within solid tumor samples. This test is not intended for use for hematological malignancies.
Highlights
Evaluates formalin-fixed, paraffin-embedded tumor or cytology slides from patients with lung cancer for rearrangements (fusions) to identify candidates for targeted therapy.
Current data suggests that lung carcinomas with ALK rearrangements may be sensitive to ALK inhibitors.
Testing Algorithm
When this test is ordered, slide review will always be performed at an additional charge.
Special Instructions
Method Name
Polymerase Chain Reaction (PCR)-Based Next Generation Sequencing
Reporting Name
Lung Rearrangement Testing, TumorSpecimen Type
VariesAdvisory Information
At least 20% tumor is required for this assay. The amount of tissue needed is dependent on a variety of preanalytical factors (eg, cellularity, ischemic time, fixation). In general, the minimum specimen adequacy for this test is approximately a 6 mm(2) area of tissue (can be over multiple slides from 1 tissue block) or 5,000 total cells (5,000 total nucleated cells if using cytology slides).
Necessary Information
Pathology report must accompany specimen in order for testing to be performed.
Specimen Required
Specimen Type: Tissue block
Collection Instructions: Submit a formalin-fixed, paraffin-embedded tissue block
Acceptable
Slides: 1 Stained and 10 unstained slides
Collection Instructions: Submit 1 slide stained with hematoxylin and eosin and 10 unstained slides (nonbaked, charged slides preferred) with 5-micron thick sections of the tumor tissue.
Specimen Type: Cytology slide (direct smears or ThinPrep)
Slides: 1-2 Slides
Collection Instructions: Submit 1-2 slides stained and coverslipped with at least 5,000 total nucleated cells
Additional Information: Cytology slides will not be returned.
Specimen Minimum Volume
Formalin-fixed, paraffin-embedded tissue block (preferred) or 1 slide stained with hematoxylin and eosin and 810 unstained slides (nonbaked, charged slides preferred) with 5- microns -thick sections of the tumor tissue with at least 6 mm(2) area of tissue (can be over multiple slides from one tissue block) and at least 20% tumor cells
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
Varies | Ambient (preferred) | ||
Frozen | |||
Refrigerated |
Reference Values
An interpretative report will be provided.
Day(s) and Time(s) Performed
Monday through Friday; Varies
Performing Laboratory

Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.CPT Code Information
81405-RET
81479-(ROS1, ALK, NTKR1)
81479 (if appropriate for government payers)
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
LUNGR | Lung Rearrangement Testing, Tumor | In Process |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
43702 | Result Summary | 50397-9 |
43703 | Result | 82939-0 |
44138 | Interpretation | 69047-9 |
44139 | Additional Information | 48767-8 |
44140 | Specimen | 31208-2 |
44141 | Source | 31208-2 |
46911 | Tissue ID | 80398-1 |
44142 | Released By | 18771-6 |
NY State Approved
YesForms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.
Additional Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
SLIRV | Slide Review in MG | No, (Bill Only) | Yes |