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Test ID LYNCP Lynch Syndrome Panel, Varies

Ordering Guidance

This gene panel tests for germline variants in the Lynch syndrome genes. This is not a tumor test or immunohistochemistry (IHC). For information on tumor testing or IHC staining for Lynch syndrome, see TMSI / Microsatellite Instability, Tumor or IHC / Mismatch Repair (MMR) Protein Immunohistochemistry Only


For a comprehensive hereditary cancer panel that includes MLH1, MSH2, MSH6, PMS2, and EPCAM genes, consider ordering 1 of the following tests:

-CRCGP / Hereditary Gastrointestinal Cancer Panel, Varies

-PANCP / Hereditary Pancreatic Cancer Panel, Varies

-PRS8P / Hereditary Prostate Cancer Panel, Varies

-BRGYP / Hereditary Breast/Gynecologic Cancer Panel, Varies


Additional first-tier testing may be considered/recommended. For more information see Lynch Syndrome Testing Algorithm.


Customization of this panel or single gene analysis for any gene present on this panel is available. For more information see CGPH / Custom Gene Panel, Hereditary, Next-Generation Sequencing, Varies.


Targeted testing for familial variants (also called site-specific or known mutations testing) is available for the genes on this panel. For more information see FMTT / Familial Mutation, Targeted Testing, Varies.

Shipping Instructions

Specimen preferred to arrive within 96 hours of collection.

Necessary Information

Prior Authorization is available for this test. Submit the required form with the specimen.

Specimen Required

Patient Preparation: A previous bone marrow transplant from an allogenic donor will interfere with testing. Call 800-533-1710 for instructions for testing patients who have received a bone marrow transplant.

Specimen Type: Whole blood


Preferred: Lavender top (EDTA) or yellow top (ACD)

Acceptable: Any anticoagulant

Specimen Volume: 3 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube. Do not aliquot.

Specimen Stability Information: Ambient (preferred) 4 days/Refrigerated


1. New York Clients-Informed consent is required. Document on the request form or electronic order that a copy is on file.

-Informed Consent for Genetic Testing  (T576)

-Informed Consent for Genetic Testing (Spanish) (T826)

2. Molecular Genetics: Inherited Cancer Syndromes Patient Information Sheet (T519)

3. Targeted Genes and Methodology Details for Lynch Syndrome Panel

4. Lynch Syndrome Panel (LYNCP) Prior Authorization Ordering Instructions

5. If not ordering electronically, complete, print, and send a Oncology Test Request (T729)

Useful For

Establishing a diagnosis of Lynch syndrome or constitutional mismatch repair deficiency allowing for targeted cancer surveillance based on associated risks


Identification of MLH1, MSH2, MSH6, PMS2, or EPCAM variants to allow for predictive testing in family members

Genetics Test Information

This test utilizes next-generation sequencing to detect single nucleotide and copy number variants in 5 genes associated with Lynch syndrome: MLH1, MSH2, MSH6, PMS2, EPCAM (copy number variant only). For additional details see Method Description, Targeted Genes and Methodology Details for Lynch Syndrome Panel.


Identification of a pathogenic variant may assist with diagnosis, prognosis, clinical management, familial screening, and genetic counseling for Lynch syndrome.


Prior Authorization is available for this assay.

Disease States

  • Lynch syndrome

Testing Algorithm

See Lynch Syndrome Testing Algorithm.

Method Name

Sequence Capture and Next-Generation Sequencing (NGS), Polymerase Chain Reaction (PCR), Sanger Sequencing and/or Multiplex Ligation-Dependent Probe Amplification (MLPA)

Reporting Name

Lynch Syndrome Panel

Specimen Type


Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Varies

Reference Values

An interpretive report will be provided.

Day(s) Performed


Report Available

3 to 4 weeks

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

CPT Code Information






LOINC Code Information

Test ID Test Order Name Order LOINC Value
LYNCP Lynch Syndrome Panel In Process


Result ID Test Result Name Result LOINC Value
614755 Test Description 62364-5
614756 Specimen 31208-2
614757 Source 31208-2
614758 Result Summary 50397-9
614759 Result 82939-0
614760 Interpretation 69047-9
614761 Resources 99622-3
614762 Additional Information 48767-8
614763 Method 85069-3
614764 Genes Analyzed 48018-6
614765 Disclaimer 62364-5
614766 Released By 18771-6

NY State Approved