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Test ID MDC2 Movement Disorder, Autoimmune Evaluation, Spinal Fluid


Specimen Required


Container/Tube: Sterile vial

Specimen Volume: 4 mL


Useful For

Evaluating patients with suspected paraneoplastic or other autoimmune movement disorders including patients with ataxia, chorea, dyskinesias, myoclonus, parkinsonism, and stiff-person spectrum

Profile Information

Test ID Reporting Name Available Separately Always Performed
MDCI Movement Disorder Interp, CSF No Yes
AMPHC Amphiphysin Ab, CSF No Yes
AGN1C Anti-Glial Nuclear Ab, Type 1 No Yes
ANN1C Anti-Neuronal Nuclear Ab, Type 1 No Yes
ANN2C Anti-Neuronal Nuclear Ab, Type 2 No Yes
ANN3C Anti-Neuronal Nuclear Ab, Type 3 No Yes
CS2CC CASPR2-IgG CBA, CSF No Yes
CRMWC CRMP-5-IgG Western Blot, CSF Yes Yes
CRMC CRMP-5-IgG, CSF No Yes
DPPIC DPPX Ab IFA, CSF No Yes
GD65C GAD65 Ab Assay, CSF Yes Yes
LG1CC LGI1-IgG CBA, CSF No Yes
GL1IC mGluR1 Ab IFA, CSF No Yes
NMDCC NMDA-R Ab CBA, CSF No Yes
PCTRC Purkinje Cell Cytoplasmc Ab Type Tr No Yes
PCA1C Purkinje Cell Cytoplasmic Ab Type 1 No Yes
PCA2C Purkinje Cell Cytoplasmic Ab Type 2 No Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
ABLTC Amphiphysin Western Blot, CSF No No
AMPIC AMPA-R Ab IF Titer Assay, CSF No No
AMPCC AMPA-R Ab CBA, CSF No No
DPPTC DPPX Ab IFA Titer, CSF No No
DPPCC DPPX Ab CBA, CSF No No
GABIC GABA-B-R Ab IF Titer Assay, CSF No No
GABCC GABA-B-R Ab CBA, CSF No No
GL1TC mGluR1 Ab IFA Titer, CSF No No
GL1CC mGluR1 Ab CBA, CSF No No
NMDIC NMDA-R Ab IF Titer Assay, CSF No No
WBNC Paraneoplas Autoantibody WBlot,CSF No No

Testing Algorithm

If IFA suggests amphiphysin antibody, then amphiphysin Western blot are performed at an additional charge.

 

If IFA pattern suggest AMPA-R antibody, then AMPA-R cell-binding assay (CBA) and AMPA-R titer are performed at an additional charge.

 

If IFA pattern suggests DPPX antibody, then DPPX CBA and DPPX titer are performed at an additional charge.

 

If IFA pattern suggests GABA-B-R antibody, then GABA-B-R CBA and GABA-B-R titer are performed at an additional charge.

 

If IFA pattern suggests mGluR1 antibody, then mGluR1 CBA and mGluR1 titer are performed at an additional charge.

 

If IFA pattern suggests NMDA-R antibody and NMDA-R CBA is positive, then NMDA-R titer is performed at an additional charge.

 

If indirect immunofluorescence assay (IFA) suggests ANN1C, ANN2C, ANN3C, PCA1C, PCA2C, PCTRC, or AGN1C, then paraneoplastic autoantibody Western blot is performed at an additional charge.

 

See Movement Disorder Autoimmune Evaluation Algorithm-Spinal Fluid in Special Instructions.

Method Name

ANN1C, ANN2C, ANN3C, PCA1C, PCA2C, PCTRC, AMPHC, CRMC, AGN1C, DPPIC, DPPTC, GL1IC, GL1TC, AMPIC, GABIC, NMDIC: Indirect Immunofluorescence Assay (IFA)

AMPCC, GABCC, NMDCC, LG1CC, CS2CC, DPPCC, GL1CC: Cell-binding Assay (CBA)

ABLTC, CRMWC, WBNC: Western Blot (WB)

GD65C: Radioimmunoassay (RIA)

Reporting Name

Movement Autoimmune Eval, CSF

Specimen Type

CSF

Specimen Minimum Volume

3.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
CSF Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values

Test ID

Reporting Name

Methodology

Reference Value

AMPHC

Amphiphysin Ab, CSF

Immunofluorescence assay (IFA)

<1:2

AGN1C

Anti-Glial Nuclear Ab, Type 1

IFA

<1:2

ANN1C

Anti-Neuronal Nuclear Ab, Type 1

IFA

<1:2

ANN2C

Anti-Neuronal Nuclear Ab, Type 2

IFA

<1:2

ANN3C

Anti-Neuronal Nuclear Ab, Type 3

IFA

<1:2

CS2CC

CASPR2-IgG CBA, CSF

Cell-binding assay (CBA)

Negative

CRMWC

CRMP-5-IgG Western Blot, CSF

Western blot (WB)

Negative

CRMC

CRMP-5-IgG, CSF

IFA

<1:2

DPPIC

DPPX Ab IFA, CSF

IFA

Negative

GD65C

GAD65 Ab Assay, CSF

Radioimmunoassay (RIA)

≤0.02 nmol/L

LG1CC

LGI1-IgG CBA, CSF

CBA

Negative

GL1IC

mGluR1 Ab IFA, CSF

IFA

Negative

NMDCC

NMDA-R Ab CBA, CSF

CBA

Negative

PCTRC

Purkinje Cell Cytoplasmic Ab Type Tr

IFA

<1:2

PCA1C

Purkinje Cell Cytoplasmic Ab Type 1

IFA

<1:2

PCA2C

Purkinje Cell Cytoplasmic Ab Type 2

IFA

<1:2

 

Reflex Information:

Test ID

Reporting Name

Methodology

Reference Value

ABLTC

Amphiphysin Western Blot, CSF

WB

Negative

AMPIC

AMPA-R Ab IF Titer Assay, CSF

IFA

<1:2

AMPCC

AMPA-R Ab CBA, CSF

CBA

Negative

DPPTC

DPPX Ab IFA Titer, CSF

IFA

<1:2

DPPCC

DPPX Ab CBA, CSF

CBA

Negative

GABIC

GABA-B-R Ab IF Titer Assay, CSF

IFA

<1:2

GABCC

GABA-B-R Ab CBA, CSF

CBA

Negative

GL1TC

mGluR1 Ab IFA Titer, CSF

IFA

<1:2

GL1CC

mGluR1 Ab CBA, CSF

CBA

Negative

NMDIC

NMDA-R Ab IF Titer Assay, CSF

IFA

<1:2

WBNC

Paraneoplastic Autoantibody WBlot, CSF

WB

Negative

 

Neuron-restricted patterns of IgG staining that do not fulfill criteria for ANNA-1, ANNA-2, CRMP-5-IgG, PCA-1, PCA-2, or PCA-Tr may be reported as "unclassified anti-neuronal IgG." Complex patterns that include nonneuronal elements may be reported as "uninterpretable."

Day(s) and Time(s) Performed

AMPHC, AGN1C, ANN1C, ANN2C, ANN3C, CRMC, DPPIC, GL1IC, PCA1C, PCA2C, PCTRC, AMPIC, DPPTC, GABIC, GL1TC, NMDIC:

Monday through Friday; 5 a.m., 7 a.m., 5 p.m.

Saturday, Sunday; 6 a.m.

 

CRMWC, ABLTC, WBNC:

Monday, Wednesday, Friday; 8 a.m.

 

GD65C:

Monday through Friday; 5 a.m., 2 p.m.

Saturday, Sunday; 7 a.m.

 

CS2CC, LG1CC, AMPCC, GABCC, NMDCC:

Monday through Thursday; 10 p.m.

Sunday; 3 p.m.

 

DPPCC, GL1CC:

Wednesday; 6 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

86255 x14

84182 x1

86341 x1

86255 x4 (if appropriate)

86256 x5 (if appropriate)

84182 x2 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MDC2 Movement Autoimmune Eval, CSF In Process

 

Result ID Test Result Name Result LOINC Value
61513 NMDA-R Ab CBA, CSF 93502-3
64280 LGI1-IgG CBA, CSF In Process
64282 CASPR2-IgG CBA, CSF In Process
64929 DPPX Ab IFA, CSF 82989-5
64927 mGluR1 Ab IFA, CSF In Process
601997 Movement Disorder Interp, CSF 69048-7
89079 AGNA-1, CSF 53714-2
5906 Amphiphysin Ab, CSF 56531-7
3852 ANNA-1, CSF 24400-4
7472 ANNA-2, CSF 24401-2
21633 ANNA-3, CSF 90837-6
21650 CRMP-5-IgG, CSF 35385-4
3988 PCA-1, CSF 53713-4
21632 PCA-2, CSF 35143-7
21631 PCA-Tr, CSF 56551-5
21747 CRMP-5-IgG Western Blot, CSF 53707-6
21702 GAD65 Ab Assay, CSF 53708-4
36429 Reflex Added 77202-0

NY State Approved

Yes

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.