Test ID MDC2 Movement Disorder, Autoimmune Evaluation, Spinal Fluid
Specimen Required
Container/Tube: Sterile vial
Specimen Volume: 4 mL
Forms
If not ordering electronically, complete, print, and send a Neurology Specialty Testing Client Test Request (T732) with the specimen.
Useful For
Evaluating patients with suspected paraneoplastic or other autoimmune movement disorders including patients with ataxia, chorea, dyskinesias, myoclonus, parkinsonism, and stiff-person spectrum using spinal fluid specimens
Profile Information
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
MDCI | Movement Disorder Interp, CSF | No | Yes |
AMPHC | Amphiphysin Ab, CSF | No | Yes |
AGN1C | Anti-Glial Nuclear Ab, Type 1 | No | Yes |
ANN1C | Anti-Neuronal Nuclear Ab, Type 1 | No | Yes |
ANN2C | Anti-Neuronal Nuclear Ab, Type 2 | No | Yes |
ANN3C | Anti-Neuronal Nuclear Ab, Type 3 | No | Yes |
CS2CC | CASPR2-IgG CBA, CSF | No | Yes |
CRMWC | CRMP-5-IgG Western Blot, CSF | Yes | Yes |
CRMC | CRMP-5-IgG, CSF | No | Yes |
DPPIC | DPPX Ab IFA, CSF | No | Yes |
GD65C | GAD65 Ab Assay, CSF | Yes | Yes |
GRFIC | GRAF1 IFA, CSF | No | Yes |
IG5IC | IgLON5 IFA, CSF | No | Yes |
ITPIC | ITPR1 IFA, CSF | No | Yes |
LG1CC | LGI1-IgG CBA, CSF | No | Yes |
GL1IC | mGluR1 Ab IFA, CSF | No | Yes |
NIFIC | NIF IFA, CSF | No | Yes |
NMDCC | NMDA-R Ab CBA, CSF | No | Yes |
PCTRC | Purkinje Cell Cytoplasmc Ab Type Tr | No | Yes |
PCA1C | Purkinje Cell Cytoplasmic Ab Type 1 | No | Yes |
PCA2C | Purkinje Cell Cytoplasmic Ab Type 2 | No | Yes |
Reflex Tests
Test ID | Reporting Name | Available Separately | Always Performed |
---|---|---|---|
AGNBC | AGNA-1 Immunoblot, CSF | No | No |
AINCC | Alpha Internexin CBA, CSF | No | No |
AMPIC | AMPA-R Ab IF Titer Assay, CSF | No | No |
AMPCC | AMPA-R Ab CBA, CSF | No | No |
AMIBC | Amphiphysin Immunoblot, CSF | No | No |
AN1BC | ANNA-1 Immunoblot, CSF | No | No |
AN2BC | ANNA-2 Immunoblot, CSF | No | No |
DPPTC | DPPX Ab IFA Titer, CSF | No | No |
DPPCC | DPPX Ab CBA, CSF | No | No |
GABIC | GABA-B-R Ab IF Titer Assay, CSF | No | No |
GABCC | GABA-B-R Ab CBA, CSF | No | No |
GRFCC | GRAF1 CBA, CSF | No | No |
GRFTC | GRAF1 IFA Titer, CSF | No | No |
IG5CC | IgLON5 CBA, CSF | No | No |
IG5TC | IgLON5 IFA Titer, CSF | No | No |
ITPCC | ITPR1 CBA, CSF | No | No |
ITPTC | ITPR1 IFA Titer, CSF | No | No |
GL1TC | mGluR1 Ab IFA Titer, CSF | No | No |
GL1CC | mGluR1 Ab CBA, CSF | No | No |
NFHCC | NIF Heavy Chain CBA, CSF | No | No |
NIFTC | NIF IFA Titer, CSF | No | No |
NFLCC | NIF Light Chain CBA, CSF | No | No |
NMDIC | NMDA-R Ab IF Titer Assay, CSF | No | No |
PC1BC | PCA-1 Immunoblot, CSF | No | No |
PCTBC | PCA-Tr Immunoblot, CSF | No | No |
Testing Algorithm
If immunofluorescence assay (IFA) pattern suggests amphiphysin antibody, then amphiphysin immunoblot are performed at an additional charge.
If IFA pattern suggests AGNA-1 antibody, then AGNA-1 immunoblot is performed at an additional charge.
If IFA pattern suggests ANNA-1 antibody, then ANNA-1 immunoblot is performed at an additional charge.
If IFA pattern suggests ANNA-2 antibody, then ANNA-2 immunoblot is performed at an additional charge.
If IFA pattern suggests PCA-1 antibody, then PCA-1 immunoblot is performed at an additional charge.
If IFA pattern suggests PCA-Tr antibody, then PCA-Tr immunoblot is performed at an additional charge.
If IFA pattern suggest AMPA-receptor antibody, then AMPA-receptor cell-binding assay (CBA) and AMPA-receptor titer are performed at an additional charge.
If IFA pattern suggests DPPX antibody, then DPPX CBA and DPPX titer are performed at an additional charge.
If IFA pattern suggests GABA-B-receptor antibody, then GABA-B-receptor CBA and GABA-B-receptor titer are performed at an additional charge.
If IFA pattern suggests mGluR1 antibody, then mGluR1 CBA and mGluR1 titer are performed at an additional charge.
If IFA pattern suggests NMDA-receptor antibody and NMDA-receptor CBA is positive, then NMDA-receptor titer is performed at an additional charge.
If IFA pattern suggests GRAF1 antibody, then GRAF1 CBA and GRAF1 titer are performed at an additional charge.
If IFA pattern suggests IgLON5 antibody, then IgLON5 CBA and IgLON5 titer are performed at an additional charge.
If IFA pattern suggests ITPR1 antibody, then ITPR1 CBA and ITPR1 titer are performed at an additional charge.
If IFA pattern suggests NIF antibody, then alpha internexin CBA, NIF heavy chain CBA, NIF light chain CBA, and NIF titer are performed at an additional charge.
See Movement Disorder Autoimmune Evaluation Algorithm-Spinal Fluid in Special Instructions.
Method Name
AGN1C, AMPHC, AMPIC, ANN1C, ANN2C, ANN3C, CRMC, DPPIC, DPPTC, GABIC, GL1IC, GL1TC, GRFIC, GRFTC, IG5IC, IG5TC, ITPIC, ITPTC, NIFIC, NIFTC, NMDIC, PCA1C, PCA2C, PCTRC: Indirect Immunofluorescence Assay (IFA)
AINCC, AMPCC, CS2CC, DPPCC, GABCC, GL1CC, GRFCC, IG5CC, ITPCC, LG1CC, NFHCC, NFLCC, NMDCC: Cell-Binding Assay (CBA)
CRMWC: Western Blot
AGNBC, AMIBC, AN1BC, AN2BC, PC1BC, PCTBC: Immunoblot
GD65C: Radioimmunoassay (RIA)
Reporting Name
Movement Autoimmune Eval, CSFSpecimen Type
CSFSpecimen Minimum Volume
3.5 mL
Specimen Stability Information
Specimen Type | Temperature | Time | Special Container |
---|---|---|---|
CSF | Refrigerated (preferred) | 28 days | |
Frozen | 28 days | ||
Ambient | 72 hours |
Reference Values
Test ID |
Reporting Name |
Methodology |
Reference Value |
AMPHC |
Amphiphysin Ab, CSF |
Immunofluorescence assay (IFA) |
<1:2 |
AGN1C |
Anti-Glial Nuclear Ab, Type 1 |
IFA |
<1:2 |
ANN1C |
Anti-Neuronal Nuclear Ab, Type 1 |
IFA |
<1:2 |
ANN2C |
Anti-Neuronal Nuclear Ab, Type 2 |
IFA |
<1:2 |
ANN3C |
Anti-Neuronal Nuclear Ab, Type 3 |
IFA |
<1:2 |
CS2CC |
CASPR2-IgG CBA, CSF |
Cell-binding assay (CBA) |
Negative |
CRMWC |
CRMP-5-IgG Western Blot, CSF |
Western blot (WB) |
Negative |
CRMC |
CRMP-5-IgG, CSF |
IFA |
<1:2 |
DPPIC |
DPPX Ab IFA, CSF |
IFA |
Negative |
GD65C |
GAD65 Ab Assay, CSF |
Radioimmunoassay (RIA) |
≤0.02 nmol/L Reference values apply to all ages. |
GRFIC |
GRAF1 IFA, CSF |
IFA |
Negative |
IG5IC |
IgLON5 IFA, CSF |
IFA |
Negative |
ITPIC |
ITPR1 IFA, CSF |
IFA |
Negative |
LG1CC |
LGI1-IgG CBA, CSF |
CBA |
Negative |
GL1IC |
mGluR1 Ab IFA, CSF |
IFA |
Negative |
NIFIC |
NIF IFA, CSF |
IFA |
Negative |
NMDCC |
NMDA-R Ab CBA, CSF |
CBA |
Negative |
PCTRC |
Purkinje Cell Cytoplasmic Ab Type Tr |
IFA |
<1:2 |
PCA1C |
Purkinje Cell Cytoplasmic Ab Type 1 |
IFA |
<1:2 |
PCA2C |
Purkinje Cell Cytoplasmic Ab Type 2 |
IFA |
<1:2 |
Reflex Information:
Test ID |
Reporting Name |
Methodology |
Reference Value |
AGNBC |
AGNA-1 Immunoblot, CSF |
Immunoblot (IB) |
Negative |
AINCC |
Alpha Internexin CBA, CSF |
CBA |
Negative |
AMPIC |
AMPA-R Ab IF Titer Assay, CSF |
IFA |
<1:2 |
AMPCC |
AMPA-R Ab CBA, CSF |
CBA |
Negative |
AMIBC |
Amphiphysin Immunoblot, CSF |
IB |
Negative |
AN1BC |
ANNA-1 Immunoblot, CSF |
IB |
Negative |
AN2BC |
ANNA-2 Immunoblot, CSF |
IB |
Negative |
DPPTC |
DPPX Ab IFA Titer, CSF |
IFA |
<1:2 |
DPPCC |
DPPX Ab CBA, CSF |
CBA |
Negative |
GABIC |
GABA-B-R Ab IF Titer Assay, CSF |
IFA |
<1:2 |
GABCC |
GABA-B-R Ab CBA, CSF |
CBA |
Negative |
GRFCC |
GRAF1 CBA, CSF |
CBA |
Negative |
GRFTC |
GRAF1 IFA Titer, CSF |
IFA |
<1:2 |
IG5CC |
IgLON5 CBA, CSF |
CBA |
Negative |
IG5TC |
IgLON5 IFA Titer, CSF |
IFA |
<1:2 |
ITPCC |
ITPR1 CBA, CSF |
CBA |
Negative |
ITPTC |
ITPR1 IFA Titer, CSF |
IFA |
<1:2 |
GL1TC |
mGluR1 Ab IFA Titer, CSF |
IFA |
<1:2 |
GL1CC |
mGluR1 Ab CBA, CSF |
CBA |
Negative |
NFHCC |
NIF Heavy Chain CBA, CSF |
CBA |
Negative |
NIFTC |
NIF IFA Titer, CSF |
IFA |
<1:2 |
NFLCC |
NIF Light Chain CBA, CSF |
CBA |
Negative |
NMDIC |
NMDA-R Ab IF Titer Assay, CSF |
IFA |
<1:2 |
PC1BC |
PCA-1 Immunoblot, CSF |
IB |
Negative |
PCTBC |
PCA-Tr Immunoblot, CSF |
IB |
Negative |
Neuron-restricted patterns of IgG staining that do not fulfill criteria for ANNA-1, ANNA-2, CRMP-5-IgG, PCA-1, PCA-2, or PCA-Tr may be reported as "unclassified anti-neuronal IgG." Complex patterns that include nonneuronal elements may be reported as "uninterpretable."
Day(s) and Time(s) Performed
AGN1C, AMPHC, AMPIC, ANN1C, ANN2C, ANN3C, CRMC, DPPIC, DPPTC, GABIC, GL1IC, GL1TC, GRFIC, GRFTC, IG5IC, IG5TC, ITPIC, ITPTC, NIFIC, NIFTC, NMDIC, PCA1C, PCA2C, PCTRC:
Monday through Friday; 5 a.m., 7 a.m., 5 p.m.
Saturday, Sunday; 6 a.m.
CRMWC:
Monday through Thursday; 8 a.m.
AGNBC, AMIBC, AN1BC, AN2BC, PC1BC, PCTBC:
Monday through Friday; 6 p.m.
GD65C:
Monday through Friday; 5 a.m., 2 p.m.
Saturday, Sunday; 7 a.m.
AMPCC, CS2CC, DPPCC, GABCC, LG1CC, NMDCC:
Monday through Friday; 10 p.m.
Sunday; 10 p.m.
GL1CC, GRFCC, IG5CC, ITPCC:
Monday, Thursday; 6 p.m.
AINCC, NFHCC, NFLCC:
Tuesday, Thursday; 6 p.m.
Performing Laboratory

CPT Code Information
86255 x18
84182 x1
86341 x1
84182 AGNBC (if appropriate)
86255 AINCC (if appropriate)
86255 AMPCC (if appropriate)
86256 AMPIC (if appropriate)
84182 AMIBC (if appropriate)
84182 AN1BC (if appropriate)
84182 AN2BC (if appropriate)
86255 DPPCC (if appropriate)
86256 DPPTC (if appropriate)
86255 GABCC (if appropriate)
86256 GABIC (if appropriate)
86255 GRFCC (if appropriate)
86256 GRFTC (if appropriate)
86255 IG5CC (if appropriate)
86256 IG5TC (if appropriate)
86255 ITPCC (if appropriate)
86256 ITPTC (if appropriate)
86255 GL1CC (if appropriate)
86256 GL1TC (if appropriate)
86255 NFHCC (if appropriate)
86256 NIFTC (if appropriate)
86255 NFLCC (if appropriate)
86256 NMDIC (if appropriate)
84182 PC1BC (if appropriate)
84182 PCTBC (if appropriate)
LOINC Code Information
Test ID | Test Order Name | Order LOINC Value |
---|---|---|
MDC2 | Movement Autoimmune Eval, CSF | 94712-7 |
Result ID | Test Result Name | Result LOINC Value |
---|---|---|
61513 | NMDA-R Ab CBA, CSF | 93502-3 |
606959 | GRAF1 IFA, CSF | 96473-4 |
606965 | NIF IFA, CSF | 96490-8 |
606947 | IgLON5 IFA, CSF | 96479-1 |
64280 | LGI1-IgG CBA, CSF | 94288-8 |
64282 | CASPR2-IgG CBA, CSF | 94286-2 |
64929 | DPPX Ab IFA, CSF | 82989-5 |
64927 | mGluR1 Ab IFA, CSF | 94361-3 |
601997 | Movement Disorder Interp, CSF | 69048-7 |
606953 | ITPR1 IFA, CSF | 96467-6 |
89079 | AGNA-1, CSF | 94355-5 |
5906 | Amphiphysin Ab, CSF | 94354-8 |
3852 | ANNA-1, CSF | 94356-3 |
7472 | ANNA-2, CSF | 94357-1 |
21633 | ANNA-3, CSF | 94358-9 |
21650 | CRMP-5-IgG, CSF | 94706-9 |
3988 | PCA-1, CSF | 94363-9 |
21632 | PCA-2, CSF | 94364-7 |
21631 | PCA-Tr, CSF | 94362-1 |
21747 | CRMP-5-IgG Western Blot, CSF | 53707-6 |
21702 | GAD65 Ab Assay, CSF | 94359-7 |
36429 | Reflex Added | 77202-0 |