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HelpTest ID METAF Metanephrines, Fractionated, 24 Hour, Urine
Useful For
A first- and second-order screening test for the presumptive diagnosis of catecholamine-secreting pheochromocytomas and paragangliomas
Confirming positive plasma metanephrine results
Special Instructions
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Stable Isotope Dilution Analysis
Reporting Name
Metanephrines, Fractionated, 24h, USpecimen Type
UrineOrdering Guidance
Necessary Information
24-Hour volume is required.
Specimen Required
Patient Preparation: Tricyclic antidepressants, labetalol, and sotalol medications may elevate levels of metanephrines producing results that cannot be interpreted. If clinically feasible, it is optimal to discontinue these medications at least 1 week before collection. For advice on assessing the risk of removing patients from these medications and alternatives, consider consultation with a specialist in endocrinology or hypertension.
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic urine tube
Specimen Volume: 10 mL
Collection Instructions:
1. Collect urine for 24 hours.
2. Add 10 g (pediatric: 3 g) of boric acid or 25 mL (pediatric: 15 mL) of 50% acetic acid as preservative at start of collection.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 28 days | |
| Ambient | 28 days | ||
| Frozen | 28 days |
Reference Values
METANEPHRINE
Males
Normotensives
3-8 years: 29-92 mcg/24 hours
9-12 years: 59-188 mcg/24 hours
13-17 years: 69-221 mcg/24 hours
≥18 years: 44-261 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <400 mcg/24 hours
Females
Normotensives
3-8 years: 18-144 mcg/24 hours
9-12 years: 43-122 mcg/24 hours
13-17 years: 33-185 mcg/24 hours
≥18 years: 30-180 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <400 mcg/24 hours
NORMETANEPHRINE
Males
Normotensives
3-8 years: 34-169 mcg/24 hours
9-12 years: 84-422 mcg/24 hours
13-17 years: 91-456 mcg/24 hours
18-29 years: 103-390 mcg/24 hours
30-39 years: 111-419 mcg/24 hours
40-49 years: 119-451 mcg/24 hours
50-59 years: 128-484 mcg/24 hours
60-69 years: 138-521 mcg/24 hours
≥70 years: 148-560 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <900 mcg/24 hours
Females
Normotensives
3-8 years: 29-145 mcg/24 hours
9-12 years: 55-277 mcg/24 hours
13-17 years: 57-286 mcg/24 hours
18-29 years: 103-390 mcg/24 hours
30-39 years: 111-419 mcg/24 hours
40-49 years: 119-451 mcg/24 hours
50-59 years: 128-484 mcg/24 hours
60-69 years: 138-521 mcg/24 hours
≥70 years: 148-560 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <900 mcg/24 hours
TOTAL METANEPHRINE
Males
Normotensives
3-8 years: 47-223 mcg/24 hours
9-12 years: 201-528 mcg/24 hours
13-17 years: 120-603 mcg/24 hours
18-29 years: 190-583 mcg/24 hours
30-39 years: 200-614 mcg/24 hours
40-49 years: 211-646 mcg/24 hours
50-59 years: 222-680 mcg/24 hours
60-69 years: 233-716 mcg/24 hours
≥70 years: 246-753 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <1,300 mcg/24 hours
Females
Normotensives
3-8 years: 57-210 mcg/24 hours
9-12 years: 107-394 mcg/24 hours
13-17 years: 113-414 mcg/24 hours
18-29 years: 142-510 mcg/24 hours
30-39 years: 149-535 mcg/24 hours
40-49 years: 156-561 mcg/24 hours
50-59 years: 164-588 mcg/24 hours
60-69 years: 171-616 mcg/24 hours
≥70 years: 180-646 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <1,300 mcg/24 hours
For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html
Day(s) Performed
Monday through Friday
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83835
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| METAF | Metanephrines, Fractionated, 24h, U | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8552 | Metanephrine, U | 19049-6 |
| 21545 | Normetanephrine, U | 2671-6 |
| 83006 | Total Metanephrines, U | 2609-6 |
| TM50 | Collection Duration | 13362-9 |
| VL48 | Urine Volume | 3167-4 |
| 2434 | Comment | 48767-8 |
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.Report Available
3 to 5 daysNY State Approved
YesForms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.