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HelpTest ID METAF Metanephrines, Fractionated, 24 Hour, Urine
Useful For
A first- and second-order screening test for the presumptive diagnosis of catecholamine-secreting pheochromocytomas and paragangliomas
Confirming positive plasma metanephrine results
Special Instructions
Method Name
Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Stable Isotope Dilution Analysis
Reporting Name
Metanephrines, Fractionated, 24h, USpecimen Type
UrineAdvisory Information
Necessary Information
24-Hour volume is required.
Specimen Required
Patient Preparation: Tricyclic antidepressants, labetalol, and sotalol medications may elevate levels of metanephrines producing results that cannot be interpreted. If clinically feasible, it is optimal to discontinue these medications at least 1 week before collection. For advice on assessing the risk of removing patients from these medications and alternatives, you may consider consultation with a specialist in endocrinology or hypertension.
Supplies: Urine Tubes, 10 mL (T068)
Container/Tube: Plastic urine tube (T068)
Specimen Volume: 10 mL
Collection Instructions:
1. Collect urine for 24 hours.
2. Add 10 g (pediatric: 3 g) of boric acid or 25 mL (pediatric: 15 mL) of 50% acetic acid as preservative at start of collection.
Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.
Specimen Minimum Volume
2 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 7 days | |
| Frozen | 14 days | ||
| Ambient | 7 days |
Reference Values
METANEPHRINE
Males
Normotensives
3-8 years: 29-92 mcg/24 hours
9-12 years: 59-188 mcg/24 hours
13-17 years: 69-221 mcg/24 hours
≥18 years: 44-261 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <400 mcg/24 hours
Females
Normotensives
3-8 years: 18-144 mcg/24 hours
9-12 years: 43-122 mcg/24 hours
13-17 years: 33-185 mcg/24 hours
≥18 years: 30-180 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <400 mcg/24 hours
NORMETANEPHRINE
Males
Normotensives
3-8 years: 34-169 mcg/24 hours
9-12 years: 84-422 mcg/24 hours
13-17 years: 91-456 mcg/24 hours
18-29 years: 103-390 mcg/24 hours
30-39 years: 111-419 mcg/24 hours
40-49 years: 119-451 mcg/24 hours
50-59 years: 128-484 mcg/24 hours
60-69 years: 138-521 mcg/24 hours
≥70 years: 148-560 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <900 mcg/24 hours
Females
Normotensives
3-8 years: 29-145 mcg/24 hours
9-12 years: 55-277 mcg/24 hours
13-17 years: 57-286 mcg/24 hours
18-29 years: 103-390 mcg/24 hours
30-39 years: 111-419 mcg/24 hours
40-49 years: 119-451 mcg/24 hours
50-59 years: 128-484 mcg/24 hours
60-69 years: 138-521 mcg/24 hours
≥70 years: 148-560 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <900 mcg/24 hours
TOTAL METANEPHRINE
Males
Normotensives
3-8 years: 47-223 mcg/24 hours
9-12 years: 201-528 mcg/24 hours
13-17 years: 120-603 mcg/24 hours
18-29 years: 190-583 mcg/24 hours
30-39 years: 200-614 mcg/24 hours
40-49 years: 211-646 mcg/24 hours
50-59 years: 222-680 mcg/24 hours
60-69 years: 233-716 mcg/24 hours
≥70 years: 246-753 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <1,300 mcg/24 hours
Females
Normotensives
3-8 years: 57-210 mcg/24 hours
9-12 years: 107-394 mcg/24 hours
13-17 years: 113-414 mcg/24 hours
18-29 years: 142-510 mcg/24 hours
30-39 years: 149-535 mcg/24 hours
40-49 years: 156-561 mcg/24 hours
50-59 years: 164-588 mcg/24 hours
60-69 years: 171-616 mcg/24 hours
≥70 years: 180-646 mcg/24 hours
Reference values have not been established for patients that are <36 months of age.
Hypertensives: <1,300 mcg/24 hours
For SI unit Reference Values, see https://www.mayocliniclabs.com/order-tests/si-unit-conversion.html
Day(s) and Time(s) Performed
Monday through Friday; 4 p.m.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
CPT Code Information
83835
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| METAF | Metanephrines, Fractionated, 24h, U | In Process |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 8552 | Metanephrine, U | 19049-6 |
| 21545 | Normetanephrine, U | 2671-6 |
| 83006 | Total Metanephrines, U | 2609-6 |
| TM50 | Collection Duration | 13362-9 |
| VL48 | Urine Volume | 3167-4 |
| 2434 | Comment | 48767-8 |
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.NY State Approved
YesForms
If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.