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Test ID MMLNS Antimicrobial Susceptibility, Nocardia species and other Aerobic Actinomycetes, Varies

Biohazard Infectious

Useful For

Determining the resistance of species of Nocardia and other aerobic actinomycetes to antimicrobial agents

Highlights

Antimicrobials tested for Nocardia species and other aerobic actinomycete susceptibility include: amikacin, amoxicillin/clavulanic acid, ceftriaxone, ciprofloxacin, clarithromycin, doxycycline, imipenem, linezolid, minocycline, moxifloxacin, trimethoprim/sulfamethoxazole, and tobramycin.

 

For Rhodococcus equi, rifampin and vancomycin will also be tested.

Method Name

Minimum Inhibitory Concentration (MIC)

Reporting Name

Susc, Aerobic Actinomycetes

Specimen Type

Varies


Shipping Instructions


1. See Infectious Specimen Shipping Guidelines in Special Instructions.

2. Place specimen in a large infectious container (T146) and label as an etiologic agent/infectious substance.



Necessary Information


Specimen source is required.



Specimen Required


Specimen Type: Organism in pure culture

Supplies: Infectious Container, Large (T146)

Container/Tube:

Preferred: Middlebrook 7H10 agar slant without antimicrobials

Acceptable: Sabouraud's dextrose agar slant or similar media without antimicrobials (eg, 7H11 agar slant, LJ, MGIT [7H9] broth media)

Specimen Volume: Isolate

Collection Instructions: Organism must be in pure culture, actively growing.


Specimen Stability Information

Specimen Type Temperature Time Special Container
Varies Ambient (preferred)
  Refrigerated 

Reference Values

The following are interpretive values for susceptibility testing of Nocardia species and other aerobic actinomycetes using a broth microdilution method. 

Antimicrobial agent

Concentration range mcg/mL

Interpretations

S

I

R

Amikacin

0.5-32

≤8

-

≥16

Amoxicillin/clavulanate

2/1-128/64

≤8/4

16/8

≥32/16

Ceftriaxone

1-64

≤8

16-32

≥64

Ciprofloxacin

0.12-16

≤1

2

≥4

Clarithromycin

0.03-16

≤2

4

≥8

Doxycycline

0.12-16

≤1

2-4

≥8

Imipenem

0.12-32

≤4

8

≥16

Linezolid

0.5-16

≤8

-

-

Minocycline

0.06-16

≤1

2-4

≥8

Moxifloxacin

0.015-8

≤1

2

≥4

Tobramycin

2-64

≤4

8

≥16

Trimethoprim/ Sulfamethoxazole

0.06/1.19-8/152

≤2/38

-

≥4/76

For Rhodococcus equi only

 

 

 

 

Rifampin

0.5-2

≤1

2

≥4

Vancomycin

0.5-16

≤2

4-8

≥16

Day(s) Performed

Monday through Sunday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

87186

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MMLNS Susc, Aerobic Actinomycetes 29577-4

 

Result ID Test Result Name Result LOINC Value
MMLNS Susc, Aerobic Actinomycetes 29577-4

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Additional Tests

Test ID Reporting Name Available Separately Always Performed
SSNS Susceptibility Nocardia species No, (Bill Only) Yes

Testing Algorithm

When this test is ordered, susceptibility for Nocardia species will be performed at an additional charge.

 

When the organism identification is Rhodococcus equi the additional reflex test will be performed at an additional charge for the additional antimicrobials vancomycin and rifampin.

Report Available

12 to 28 days

NY State Approved

Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
MIC Susceptibility, MIC No, (Bill Only) No

Forms

If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.