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Test ID MPLB MPL Exon 10 Mutation Detection, Blood

Useful For

Aiding in the distinction between a reactive cytosis and a myeloproliferative neoplasm in blood specimens

Method Name

Mutation Detection in DNA Using Sanger Sequencing

Reporting Name

MPL Exon 10 Mutation Detection, B

Specimen Type

Whole blood

Shipping Instructions

Specimen must arrive within 7 days (168 hours) of collection.

Necessary Information

Collection date is required.

Specimen Required


Preferred: EDTA (lavender top)

Acceptable: ACD (yellow top)

Specimen Volume: 4 mL

Collection Instructions:

1. Invert several times to mix blood.

2. Send specimen in original tube.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time
Whole blood Ambient (preferred) 7 days
  Refrigerated  7 days

Reference Values

An interpretive report will be provided.

Day(s) and Time(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

81403-MPL (myeloproliferative leukemia virus oncogene, thrombopoietin receptor, TPOR) (eg, myeloproliferative disorder), exon 10 sequence

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MPLB MPL Exon 10 Mutation Detection, B In Process


Result ID Test Result Name Result LOINC Value
19997 Final Diagnosis: 34574-4

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Testing Algorithm

See Myeloproliferative Neoplasm: A Diagnostic Approach to Peripheral Blood Evaluation in Special Instructions.


1. Hematopathology Patient Information (T676) in Special Instructions

2. If not ordering electronically, complete, print, and send a Hematopathology/Cytogenetics Test Request (T726) with the specimen.