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Test ID MPSEX Monoclonal Protein Study, Expanded Panel, Serum

Useful For

Diagnosis of monoclonal gammopathies

 

Eliminating the need for urine monoclonal studies as a part of initial diagnostic studies (ie, rule-out monoclonal gammopathy)

 

Assessing risk of progression from monoclonal gammopathy of undetermined significance to multiple myeloma

Method Name

TPE: Biuret

ELP: Agarose Gel Electrophoresis

IMFX: Immunofixation

KFLC, LFLC, KLR: Nephelometry

Reporting Name

MPSS Expanded Panel, S

Specimen Type

Serum


Specimen Required


Patient Preparation: Fasting preferred but not required

Container/Tube: 

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 2 mL


Specimen Minimum Volume

1.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reference Values

PROTEIN, TOTAL

≥1 year: 6.3-7.9 g/dL

Reference values have not been established for patients that are <12 months of age.

 

PROTEIN ELECTROPHORESIS

Albumin: 3.4-4.7 g/dL

Alpha-1-globulin: 0.1-0.3 g/dL

Alpha-2-globulin: 0.6-1.0 g/dL

Beta-globulin: 0.7-1.2 g/dL

Gamma-globulin: 0.6-1.6 g/dL

An interpretive comment is provided with the report.

 

IMMUNOFIXATION

No monoclonal protein detected

 

KAPPA-FREE LIGHT CHAIN

0.33-1.94 mg/dL

 

LAMBDA-FREE LIGHT CHAIN

0.57-2.63 mg/dL

 

KAPPA/LAMBDA-FREE LIGHT-CHAIN RATIO

0.26-1.65

Day(s) and Time(s) Performed

Monday through Saturday; 2 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83883 x 2

84155

84165

86334

LOINC Code Information

Test ID Test Order Name Order LOINC Value
MPSEX MPSS Expanded Panel, S In Process

 

Result ID Test Result Name Result LOINC Value
81653 Immunofixation 74665-1
KFLC Kappa Free Light Chain, S 36916-5
KLR Kappa/Lambda FLC Ratio 48378-4
LFLC Lambda Free Light Chain, S 33944-0
TPE Total Protein 2885-2
2769 Albumin 2862-1
2770 Alpha-1 Globulin 2865-4
2771 Alpha-2 Globulin 2868-8
2773 Beta-Globulin 2871-2
2774 Gamma-Globulin 2874-6
2785 A/G Ratio 44429-9
22308 M spike 33358-3
22309 M spike 33358-3
15254 Impression 12851-2

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Testing Algorithm

Includes total protein, serum protein electrophoresis (SPEP), heavy chain and light chain typing (kappa and lambda).

Profile Information

Test ID Reporting Name Available Separately Always Performed
TPE Total Protein Yes, (order TP) Yes
ELP Protein Electrophoresis Yes, (order PEL) Yes
IMFX Immunofixation Yes, (order IMFXO) Yes
KFLC Kappa Free Light Chain, S Yes, (order FLCP) Yes
LFLC Lambda Free Light Chain, S Yes, (order FLCP) Yes
KLR Kappa/Lambda FLC Ratio Yes, (order FLCP) Yes

NY State Approved

Yes

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.