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Test ID NICRU Nickel/Creatinine Ratio, Random, Urine

Useful For

Urine nickel is the test of choice for detecting nickel toxicity in patients exposed to nickel carbonyl.

Method Name

NICR: Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

CDCR: Enzymatic Colorimetric Assay

Reporting Name

Nickel/Creat Ratio, Random, U

Specimen Type


Specimen Required

Patient Preparation: High concentrations of gadolinium and iodine are known to interfere with most metals tests. If gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours.

Supplies: Plastic, 10-mL urine tube (T068)

Specimen Volume: 3 mL

Collection Instructions:

1. Collect a random urine specimen in a plastic 10-mL urine tube (T068) or a clean, plastic aliquot container with no metal cap or glued insert

2. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Specimen Minimum Volume

1.2 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reference Values

0-17 years: not established

Males ≥18 years: <3.8 mcg/g creatinine

Females ≥18 years: <4.3 mcg/g creatinine

Day(s) and Time(s) Performed

Thursday; 8 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

83885 Nickel Concentration

82570 Creatinine Concentration

LOINC Code Information

Test ID Test Order Name Order LOINC Value
NICRU Nickel/Creat Ratio, Random, U 13472-6


Result ID Test Result Name Result LOINC Value
CDCR Creatinine Conc 2161-8
32875 Nickel/Creat Ratio, U 13472-6

Test Classification

See Individual Test IDs

Profile Information

Test ID Reporting Name Available Separately Always Performed
NICR Nickel/Creat Ratio, U No Yes
CDCR Creatinine Conc No Yes

NY State Approved