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Test ID OPATU Opiates Confirmation, Random, Urine

Useful For

Detection and quantification of codeine, hydrocodone, oxycodone, morphine, hydromorphone, oxymorphone, noroxycodone, noroxymorphone, norhydrocodone, dihydrocodeine, and naloxone in urine

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Opiate Confirmation, U

Specimen Type


Ordering Guidance

For situations where chain of custody is required, a Chain-of-Custody Kit (T282) is available. For chain-of-custody testing, order OPATX / Opiates Confirmation, Chain of Custody, Random, Urine.


Additional drug panels and specific requests are available; call 800-533-1710 or 507-266-5700.

Additional Testing Requirements

If urine creatinine is required or adulteration of the sample is suspected, the following test should also be ordered, ADULT / Adulterants Survey, Random, Urine.

Specimen Required

Supplies: Sarstedt Aliquot Tube, 5 mL (T914)

Collection Container/Tube: Plastic urine container

Submission Container/Tube: Plastic, 5-mL tube

Specimen Volume: 3 mL

Collection Instructions:

1. Collect a random urine specimen.

2. No preservative.

Additional Information:

1. No specimen substitutions.

2. STAT requests are not accepted for this test.

3. Submitting less than 1 mL will compromise our ability to perform all necessary testing.

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reference Values


Cutoff concentrations by liquid chromatography-tandem mass spectroscopy:

Codeine: 25 ng/mL

Dihydrocodeine: 25 ng/mL

Hydrocodone: 25 ng/mL

Norhydrocodone: 25 ng/mL

Hydromorphone: 25 ng/mL

Oxycodone: 25 ng/mL

Noroxycodone: 25 ng/mL

Oxymorphone: 25 ng/mL

Noroxymorphone: 25 ng/mL

Naloxone: 25 ng/mL

Morphine: 25 ng/mL

Day(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information




G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OPATU Opiate Confirmation, U In Process


Result ID Test Result Name Result LOINC Value
6543 Codeine-by LC-MS/MS 16250-3
42000 Dihydrocodeine-by LC-MS/MS 19448-0
21177 Hydrocodone-by LC-MS/MS 16252-9
42001 Norhydrocodone-by LC-MS/MS 61422-2
21179 Hydromorphone-by LC-MS/MS 16998-7
21178 Oxycodone-by LC-MS/MS 16249-5
42002 Noroxycodone-by LC-MS/MS 61425-5
35023 Oxymorphone-by LC-MS/MS 17395-5
42003 Noroxymorphone-by LC-MS/MS 90894-7
42004 Naloxone-by LC-MS/MS 77207-9
6542 Morphine-by LC-MS/MS 16251-1
21180 Opiates Interpretation 18390-5

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

Report Available

3 to 5 days

NY State Approved



If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.