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Test ID OPTMX Opiate Confirmation, Chain of Custody, Meconium

Useful For

Detection of maternal prenatal opiate/opioid use up to 5 months before birth


Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was under the control of personnel involved with testing the specimen at all times; this control implies that the opportunity for specimen tampering would be limited. Since the evidence of illicit drug use during pregnancy can be cause for separating the baby from the mother, a complete chain of custody ensures that the test results are appropriate for legal proceedings.

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Opiate Confirmation, CoC, M

Specimen Type


Specimen Required

Supplies: Chain of Custody Meconium Kit (T653) includes the specimen containers, seals, and documentation required.

Specimen Volume: 1 g (approximately 1 teaspoon)

Collection Instructions: Collect entire random meconium specimen.

Additional Information:

1. Specimen that arrives with a broken seal does not meet the chain of custody requirements.

2. The laboratory recommends sending chain-of-custody specimens by overnight shipment.

Specimen Minimum Volume

0.3 g (approximately 1/4 teaspoon)

Specimen Stability Information

Specimen Type Temperature Time Special Container
Meconium Frozen (preferred) 28 days
  Refrigerated  28 days
  Ambient  14 days

Reference Values


Positives are reported with a quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) result.

Cutoff concentrations for LC-MS/MS testing:

Codeine: 20 ng/mL

Hydrocodone: 20 ng/mL

Hydromorphone: 20 ng/mL

Morphine: 20 ng/mL

Oxycodone: 20 ng/mL

Oxymorphone: 20 ng/mL

Day(s) Performed

Monday through Sunday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information



G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OPTMX Opiate Confirmation, CoC, M 69026-3


Result ID Test Result Name Result LOINC Value
36221 Morphine 69027-1
36222 Oxymorphone 69028-9
36223 Hydromorphone 68541-2
36224 Codeine 68542-0
36225 Oxycodone 68543-8
36226 Hydrocodone 68544-6
36227 Interpretation 8215-6
36228 Chain of Custody 77202-0

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

Additional Tests

Test ID Reporting Name Available Separately Always Performed
COCH Chain of Custody Processing No Yes

Report Available

2 days

NY State Approved



1. Chain of Custody Request is included in the Chain-of-Custody Meconium Kit (T653).

2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.