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Test ID OXYCX Oxycodone with Metabolite Confirmation, Chain of Custody, Random, Urine

Useful For

Detection and quantification of oxycodone, oxymorphone, noroxycodone, and noroxymorphonein urine


Chain of custody is required whenever the results of testing could be used in a court of law. Its purpose is to protect the rights of the individual contributing the specimen by demonstrating that it was under the control of personnel involved with testing the specimen at all times; this control implies that the opportunity for specimen tampering would be limited.

Method Name

Immunoassay/Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Oxycodone w/metabolite Conf, CoC, U

Specimen Type


Specimen Required

Container/Tube: Chain-of-Custody Kit (T282) containing the specimen containers, seals, and documentation required.

Specimen Volume: 20 mL

Collection Instructions: Collect specimen in the container provided, seal, and submit with the associated documentation to satisfy the legal requirements for chain-of-custody testing.

Specimen Minimum Volume

2.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  14 days

Reference Values


Cutoff concentrations:

Oxycodone Immunoassay screen: 100 ng/mL

Oxycodone-by LC-MS/MS: 25 ng/mL

Noroxycodone-by LC-MS/MS: 25 ng/mL

Oxymorphone-by LC-MS/MS: 25 ng/mL

Noroxymorphone-by LC-MS/MS: 25 ng/mL

Day(s) Performed

Monday through Friday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information


G0480 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
OXYCX Oxycodone w/metabolite Conf, CoC, U 94304-3


Result ID Test Result Name Result LOINC Value
36300 Oxycodone Immunoassay Screen 19642-8
61728 Oxycodone-by LC-MS/MS 16249-5
42012 Noroxycodone-by LC-MS/MS 61425-5
35964 Oxymorphone-by LC-MS/MS 17395-5
42013 Noroxymorphone-by LC-MS/MS 90894-7
36023 Oxycodone Interpretation 19643-6
36028 Chain of Custody 77202-0

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

Additional Tests

Test ID Reporting Name Available Separately Always Performed
COCH Chain of Custody Processing No Yes
ADLTX Adulterants Survey, CoC, U Yes Yes

Testing Algorithm

Adulterants testing will be performed on all chain of custody urine samples as per regulatory requirements.

Report Available

2 to 5 days

NY State Approved



1. Chain-of-Custody Request is included in the Chain-of-Custody Kit (T282).

2. If not ordering electronically, complete, print, and send a Therapeutics Test Request (T831) with the specimen.