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Test ID OXYWB Oxysterols, Blood

Ordering Guidance

This test's clinical sensitivity and specificity for the identification of Niemann-Pick type C (NPC) is 75% and 89%, respectively. If NPC is strongly suspected, OXNP / Oxysterols, Plasma is recommended.

Specimen Required


Preferred: Lavender top (EDTA)

Acceptable: Green top (sodium heparin, lithium heparin) or yellow top (ACD B)

Specimen Volume: 1 mL


If not ordering electronically, complete, print, and send an Inborn Errors of Metabolism Test Request (T798) with the specimen.

Useful For

Investigation of possible diagnoses of Niemann-Pick disease types A, B, or C in blood spot specimens


Monitoring of individuals with Niemann-Pick type C disease


This test is not suitable for the identification of carriers.

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

Reporting Name

Oxysterols, B

Specimen Type

Whole blood

Specimen Minimum Volume

0.25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Refrigerated (preferred) 72 hours
  Ambient  48 hours

Reference Values


Cutoff: ≤0.800 nmol/mL



Cutoff: ≤0.100 nmol/mL

Day(s) Performed

Tuesday; Specimens must be received by Monday for preanalytical processing

Report Available

2 to 9 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
OXYWB Oxysterols, B 92738-4


Result ID Test Result Name Result LOINC Value
BA4354 Interpretation (OXYWB) 59462-2
BA4352 Cholestane-3beta,5alpha,6beta-triol 92756-6
BA4353 Lyso-sphingomyelin 92748-3
BA4355 Reviewed By 18771-6

NY State Approved