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Test ID PA2RI Phospholipase A2 Receptor Indirect Immunofluorescence Assay, Serum

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 1 mL 

Collection Instructions:

1. Serum gel tubes should be centrifuged within 2 hours of collection.

2. Red-top tubes should be centrifuged and aliquoted within 2 hours of collection.

Useful For

Distinguishing primary from secondary membranous nephropathy


Screening for anti-PLA2R antibodies


Monitoring patients with membranous nephropathy at very low antibody titres


Anti-phospholipase A2 Receptor (PLA2R) antibodies are highly specific for the diagnosis of primary membranous nephropathy.


As many as 70% to 75% of patients with primary membranous nephropathy are positive for anti-PLA2R.

Method Name

Indirect Immunofluorescence Assay (IFA)

Reporting Name

Phospholipase A2 Receptor IFA, S

Specimen Type


Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  8 hours

Reference Values


Day(s) Performed

Monday, Wednesday, Friday

Report Available

3 to 7 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PA2RI Phospholipase A2 Receptor IFA, S 82991-1


Result ID Test Result Name Result LOINC Value
PA2RI Phospholipase A2 Receptor IFA, S 82991-1

NY State Approved



If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.