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Test ID PLPMA Prolactin, Pituitary Macroadenoma, Serum

Useful For

Quantifying prolactin in serum specimens where the high-dose hook effect is suspected (eg, presence of pituitary tumor with symptoms of prolactinoma, and lower than expected serum prolactin concentration)

Method Name

Electrochemiluminescent Immunoassay

Reporting Name

Prolactin, Pituitary Macroadenoma

Specimen Type


Ordering Guidance

For initial patient assessment; order PRL / Prolactin, Serum as the screening test.

Necessary Information

Patient's age and sex are required.

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Specimen Minimum Volume

1.75 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 7 days
  Frozen  90 days
  Ambient  24 hours

Reference Values


<18 years: not established

≥18 years: 4.0-15.2 ng/mL



<18 years: not established

≥18 years: 4.8-23.3 ng/mL 

Day(s) Performed

Monday through Sunday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PLPMA Prolactin, Pituitary Macroadenoma 20568-2


Result ID Test Result Name Result LOINC Value
PRLR Prolactin, S 20568-2
CMT89 Comment 48767-8

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Testing Algorithm

A pituitary adenoma should be identified by imaging studies prior to ordering this test.

Report Available

Same day/1 to 2 days

NY State Approved



If not ordering electronically, complete, print, and send an Oncology Test Request (T729) with the specimen.