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Test ID PYR Pyruvic Acid, Blood

Useful For

Screening for possible disorders of mitochondrial metabolism, when used in conjunction with blood lactate collected at the same time, to determine the lactate-to-pyruvate ratio

Genetics Test Information

The lactate:pyruvate (L:P) ratio is considered a helpful (not diagnostic) tool in the evaluation of patients with possible disorders of mitochondrial metabolism, especially in patients with neurologic dysfunction and either elevated or normal blood lactate levels. Pyruvic acid levels alone have little clinical utility.

Method Name

Spectrophotometry (SP)

Reporting Name

Pyruvic Acid, B

Specimen Type

Whole blood

Additional Testing Requirements

This test does not calculate the lactate:pyruvate ratio. To obtain this information, both this test and LACS1 / Lactate, Plasma must be ordered. The ratio can be calculated from the results obtained from these tests. A separate specimen must be obtained for lactate testing, see LACS1 / Lactate, Plasma.

Specimen Required

Call 800-533-1710 or 507-266-5700 to order special collection tube.


Patient Preparation: Fasting (at least 4 hours)

Supplies: Perchloric Acid-Pyruvate Tube (T012)

Container/Tube: Special collection tube containing 2.5 mL of 6% perchloric acid

Specimen Volume: Exactly 1 mL

Collection Instructions:

1. Special collection tube must be prechilled prior to collection.

2. Draw enough blood directly into syringe to add exactly 1 mL of blood to the prechilled special collection tube.

3. Taking care to not spill any of the preservative, cautiously remove the cap from the tube.

4. Immediately transfer blood, once drawn, to the prechilled, special collection tube, recap, and shake vigorously to mix.

Additional Information:

1. Check expiration date before using. Supplied collection tube expires 12 months after preparation.

2. If perchloric acid (preservative) spills, obtain a new, prechilled tube.

Specimen Minimum Volume

See Specimen Required

Specimen Stability Information

Specimen Type Temperature Time Special Container
Whole blood Refrigerated 15 days PYRUVATE

Reference Values

0.08-0.16 mmol/L


NIH Unit

0.7-1.4 mg/dL

Day(s) Performed

Monday, Wednesday

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
PYR Pyruvic Acid, B 14121-8


Result ID Test Result Name Result LOINC Value
8657 Pyruvic Acid, B 14121-8
7729 Pyruvic Acid, B 2905-8

Test Classification

This test was developed, and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the US Food and Drug Administration.

Report Available

4 to 8 days

NY State Approved