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HelpTest ID QMPSS Monoclonal Protein Study, Quantitative, Serum
Ordering Guidance
Additional Testing Requirements
Quantitation of monoclonal protein alone is not considered an adequate screen for monoclonal gammopathies. When screening a patient or establishing a first-time diagnosis for a monoclonal gammopathy, order FLCS / Immunoglobulin Free Light Chains, Serum in addition to this test.
Specimen Required
Supplies: Sarstedt Aliquot Tube, 5 mL (T914)
Collection Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Submission Container/Tube: Plastic vial
Specimen Volume: 2 mL total in 2 separate plastic vials, each containing 1 mL
Collection Instructions: Centrifuge and aliquot serum into 2 plastic vials, each containing 1 mL
Useful For
Aiding in the diagnosis and monitoring of monoclonal gammopathies, when used in conjunction with free light chain studies
This test alone is not considered an adequate screen for monoclonal gammopathies.
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| QMPTS | Quantitative M-protein Isotype, S | No | Yes |
| IGA | Immunoglobulin A (IgA), S | Yes, (Order IMMG or IGA) | Yes |
| IGM | Immunoglobulin M (IgM), S | Yes, (Order IMMG or IGM) | Yes |
| IGG | Immunoglobulin G (IgG), S | Yes, (Order IMMG or IGG) | Yes |
| TMAB1 | Therapeutic Antibody Administered? | No | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IFXED | Immunofixation Delta and Epsilon, S | Yes | No |
| IGD | Immunoglobulin D (IgD), S | Yes | No |
| IGE | Immunoglobulin E (IgE), S | Yes | No |
Testing Algorithm
This test includes quantitation of monoclonal-protein isotype and immunoglobulins G, A, and M.
If a light chain is identified without a corresponding heavy chain during initial testing, then immunofixation with immunoglobulin D (IgD) and immunoglobulin E (IgE) will be performed at an additional charge.
If a monoclonal IgD or IgE is identified during initial testing, then IgD or IgE testing will be performed at an additional charge.
For more information see:
-Multiple Myeloma: Laboratory Screening
Method Name
QMPTS: Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry (MALDI-TOF MS)
IGG, IGA, IGM: Nephelometry
TMAB1: Patient Information
Reporting Name
Quantitative M-protein Study, SSpecimen Type
SerumSpecimen Minimum Volume
1.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Serum | Refrigerated (preferred) | 28 days | |
| Frozen | 28 days | ||
| Ambient | 7 days |
Reference Values
Monoclonal-protein Isotype Flag:
Negative
Interpretation:
No monoclonal protein detected.
IgG:
0-<5 months: 100-334 mg/dL
5-<9 months: 164-588 mg/dL
9-<15 months: 246-904 mg/dL
15-<24 months: 313-1,170 mg/dL
2-<4 years: 295-1,156 mg/dL
4-<7 years: 386-1,470 mg/dL
7-<10 years: 462-1,682 mg/dL
10-<13 years: 503-1,719 mg/dL
13-<16 years: 509-1,580 mg/dL
16-<18 years: 487-1,327 mg/dL
≥18 years: 767-1,590 mg/dL
IgA:
0-<5 months: 7-37 mg/dL
5-<9 months: 16-50 mg/dL
9-<15 months: 27-66 mg/dL
15-<24 months: 36-79 mg/dL
2-<4 years: 27-246 mg/dL
4-<7 years: 29-256 mg/dL
7-<10 years: 34-274 mg/dL
10-<13 years: 42-295 mg/dL
13-<16 years: 52-319 mg/dL
16-<18 years: 60-337 mg/dL
≥18 years: 61-356 mg/dL
IgM:
0-<5 months: 26-122 mg/dL
5-<9 months: 32-132 mg/dL
9-<15 months: 40-143 mg/dL
15-<24 months: 46-152 mg/dL
2-<4 years: 37-184 mg/dL
4-<7 years: 37-224 mg/dL
7-<10 years: 38-251 mg/dL
10-<13 years: 41-255 mg/dL
13-<16 years: 45-244 mg/dL
16-<18 years: 49-201 mg/dL
≥18 years: 37-286 mg/dL
Day(s) Performed
Monday through Friday
Report Available
2 to 4 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
0077U
82784 x 3
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| QMPSS | Quantitative M-protein Study, S | 104266-2 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| TMAB1 | Therapeutic Antibody Administered? | 98855-0 |
| IGA | Immunoglobulin A (IgA), S | 2458-8 |
| IGG | Immunoglobulin G (IgG), S | 2465-3 |
| IGM | Immunoglobulin M (IgM), S | 2472-9 |
| 620875 | M-protein GK | 74862-4 |
| 620876 | M-protein GL | 74863-2 |
| 620877 | M-protein AK | 74864-0 |
| 620878 | M-protein AL | 74865-7 |
| 620879 | M-protein MK | 74866-5 |
| 620880 | M-protein ML | 74867-3 |
| 620881 | Glycosylation | 104267-0 |
| 620874 | Flag, M-protein Isotype | 94400-9 |
| 621012 | QMPTS Interpretation | 69048-7 |
Special Instructions
Forms
If not ordering electronically, complete, print, and send 1 of the following forms with the specimen:
-Hematopathology/Cytogenetics Test Request (T726)
-Renal Diagnostics Test Request (T830)
-General Request (T239)