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Test ID RMPSU Monoclonal Protein Study, Random, Urine

Useful For

Diagnosing monoclonal gammopathies

Method Name

PTCON: Turbidimetry

RPEU: Agarose Gel Electrophoresis

RIFXU: Immunofixation

Reporting Name

Monoclonal Protein Study, Random, U

Specimen Type


Advisory Information

The use of a random urine specimen is sufficient for identifying the presence or absence of a monoclonal immunoglobulin, but a 24-hour specimen is preferred for quantitating and monitoring the abnormality. See MPSU / Monoclonal Protein Study, 24 Hour, Urine.

Shipping Instructions

Refrigerate specimen during collection and send refrigerated.

Necessary Information

Random urine, no volume is required.

Specimen Required


Urine Container, 60 mL (T313)

Aliquot Tube, 5 mL (T465)

Submission Container/Tube: Plastic, 60-mL urine bottle and plastic, 5-mL tube

Specimen Volume: 50 mL

Collection Instructions:

1. Collect a random urine specimen.

2. Aliquot at least 25-mL specimen in plastic, 60-mL urine bottle and at least 1-mL of specimen in plastic, 5-mL tube.

3. Label specimens appropriately (60-mL bottle for protein electrophoresis and 5-mL tube for protein, total).

Specimen Minimum Volume

25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  5 days
  Ambient  72 hours

Reference Values


No reference values apply to random urine.



The following fractions, if present, will be reported as a percent of the total protein:






Day(s) and Time(s) Performed

Protein, Total: Monday through Sunday; Continuously

Electrophoresis, Protein: Monday through Saturday; 12 p.m.

Immunofixation: Monday through Saturday; 8 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information




LOINC Code Information

Test ID Test Order Name Order LOINC Value
RMPSU Monoclonal Protein Study, Random, U In Process


Result ID Test Result Name Result LOINC Value
33039 Albumin 13992-3
33040 Alpha 1-Globulin 13990-7
33041 Alpha 2-Globulin 13993-1
33042 Beta-Globulin 13994-9
33043 Gamma-Globulin 13995-6
33044 A/G Ratio 44293-9
33045 M spike 42483-8
33046 M spike 42483-8
33047 Impression 49299-1
PTCON Protein, Total, Random, U 2888-6
32526 Immunofixation, Random, U 74666-9

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Profile Information

Test ID Reporting Name Available Separately Always Performed
RPEU Protein Electrophoresis, Random, U No Yes
RIFXU Immunofixation, Random, U No Yes
PTCON Protein, Total, Random, U No Yes

Testing Algorithm

The following algorithms are available in Special Instructions:

-Laboratory Approach to the Diagnosis of Amyloidosis

-Laboratory Screening Tests for Suspected Multiple Myeloma

NY State Approved



If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.