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Test ID RMPSU Monoclonal Protein Study, Random, Urine

Useful For

Diagnosing monoclonal gammopathies

Method Name

PTCON: Turbidimetry

RPEU: Agarose Gel Electrophoresis

RIFXU: Immunofixation

Reporting Name

Monoclonal Protein Study, Random, U

Specimen Type

Urine


Advisory Information


The use of a random urine specimen is sufficient for identifying the presence or absence of a monoclonal immunoglobulin, but a 24-hour specimen is preferred for quantitating and monitoring the abnormality. See MPSU / Monoclonal Protein Study, 24 Hour, Urine.



Shipping Instructions


Refrigerate specimen during collection and send refrigerated.



Necessary Information


Random urine, no volume is required.



Specimen Required


Supplies: Aliquot Tube, 5 mL (T465)

Container/Tube: Plastic, 60-mL urine bottle and plastic, 5-mL tube (T465)

Specimen Volume: 50 mL

Collection Instructions:

1. Collect a random urine specimen.

2. Aliquot specimen between containers.

3. Label specimens appropriately (60-mL urine bottle for protein electrophoresis and immunofixation and 5-mL tube for protein, total).


Specimen Minimum Volume

25 mL

Specimen Stability Information

Specimen Type Temperature Time
Urine Refrigerated (preferred) 14 days
  Frozen  5 days
  Ambient  72 hours

Reference Values

PROTEIN, TOTAL

No reference values apply to random urine.

 

ELECTROPHORESIS, PROTEIN

The following fractions, if present, will be reported as a percent of the total protein:

Albumin

Alpha-1-globulin

Alpha-2-globulin

Beta-globulin

Gamma-globulin

Day(s) and Time(s) Performed

Protein, Total: Monday through Sunday; Continuously

Electrophoresis, Protein: Monday through Saturday; 12 p.m.

Immunofixation: Monday through Saturday; 8 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

84156

84166

86335

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RMPSU Monoclonal Protein Study, Random, U In Process

 

Result ID Test Result Name Result LOINC Value
33039 Albumin 13992-3
33040 Alpha 1-Globulin 13990-7
33041 Alpha 2-Globulin 13993-1
33042 Beta-Globulin 13994-9
33043 Gamma-Globulin 13995-6
33044 A/G Ratio 44293-9
33045 M spike 42483-8
33046 M spike 42483-8
33047 Impression 49299-1
PTCON Protein, Total, Random, U 2888-6
32526 Immunofixation, Random, U 74666-9

Test Classification

This test has been cleared or approved by the U.S. Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

Testing Algorithm

The following algorithms are available in Special Instructions:

-Laboratory Approach to the Diagnosis of Amyloidosis

-Laboratory Screening Tests for Suspected Multiple Myeloma

NY State Approved

Yes

Profile Information

Test ID Reporting Name Available Separately Always Performed
RPEU Protein Electrophoresis, Random, U No Yes
RIFXU Immunofixation, Random, U No Yes
PTCON Protein, Total, Random, U No Yes

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection. 

Ambient

Yes

Refrigerate

Preferred

Frozen

Yes

50% Acetic Acid

No

Boric Acid

No

Diazolidinyl Urea

No

6M Hydrochloric Acid

No

6M Nitric Acid

No

Sodium Carbonate

No

Thymol

Yes

Toluene

Yes