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HelpTest ID RMPU Monoclonal Protein Studies, Random, Urine
Ordering Guidance
The use of a random urine specimen is sufficient for identifying the presence or absence of monoclonal proteins, but a 24-hour specimen is preferred for quantitating and monitoring the abnormality. See SMPU / Monoclonal Protein Studies, 24 Hour, Urine.
Shipping Instructions
Refrigerate specimen during collection and send refrigerated.
Specimen Required
Supplies: Urine Container, 60 mL (T313)
Submission Container/Tube: Plastic, 60-mL urine bottle
Specimen Volume: 50 mL
Collection Instructions:
1. Collect a random urine specimen.
2. Aliquot between 30 mL and 50 mL of urine into a plastic, 60-mL urine bottle.
Useful For
Identifying monoclonal gammopathies using random urine specimens
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| MPTRU | M-protein Mass-Fix, Random, U | No | Yes |
| RPEU | Protein Electrophoresis, Random, U | No | Yes |
| RPTU2 | Protein/Creatinine Ratio, Random, U | Yes, (RPTU1) | Yes |
Testing Algorithm
The following algorithms are available:
Special Instructions
Method Name
MPTRU: Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS)
RPEU: Agarose Gel Electrophoresis
RPTU2: Turbidimetry/Enzymatic Colorimetric Assay
Reporting Name
M-protein Studies, Random, USpecimen Type
UrineSpecimen Minimum Volume
30 mL
Specimen Stability Information
| Specimen Type | Temperature | Time | Special Container |
|---|---|---|---|
| Urine | Refrigerated (preferred) | 14 days | |
| Frozen | 5 days | ||
| Ambient | 24 hours |
Reference Values
CREATININE:
≥18 years old: 16-326 mg/dL
Reference values have not been established for patients younger than 18 years of age.
PROTEIN/CREATINE RATIO:
≥18 years: <0.18 mg/mg creatinine
Reference values have not been established for patients younger than 18 years of age.
ELECTROPHORESIS, PROTEIN:
The following fractions, if present, will be reported as mg/dL:
Albumin
Alpha-1 globulin
Alpha-2 globulin
Beta globulin
Gamma globulin
No reference values apply to random urines.
MASS-FIX M-PROTEIN ISOTYPE:
M-protein Isotype MS:
No monoclonal protein detected
Flag M-protein Isotype MS:
Negative
Day(s) Performed
Monday through Friday
Report Available
4 to 6 daysPerforming Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. It has not been cleared or approved by the US Food and Drug Administration.CPT Code Information
84156
82570
84166
0077U
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| RMPU | M-protein Studies, Random, U | 101909-0 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| 607975 | Albumin | 6942-7 |
| 617119 | M-protein Isotype MS, Random, U | In Process |
| PTCN1 | Protein, Total, Random, U | 2888-6 |
| 617120 | Flag M-protein Isotype MS, Random, U | No LOINC Needed |
| CRTR1 | Creatinine, Random, U | 2161-8 |
| 607976 | Alpha-1 globulin | 9734-5 |
| 607977 | Alpha-2 globulin | 38190-5 |
| PCRT1 | Protein/Creatinine Ratio | 2890-2 |
| 607978 | Beta globulin | 9744-4 |
| 607979 | Gamma globulin | 9745-1 |
| 33044 | A/G Ratio | 44293-9 |
| 33045 | M spike | 40661-1 |
| 33046 | M spike | 40661-1 |
| 33047 | Impression | 49299-1 |
Forms
If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.