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Test ID RPRRT Rapid Plasma Reagin Screen Response to Therapy, Serum

Ordering Guidance

This test is for monitoring response to therapy in patients treated for a syphilis infection. To screen patients for an undiagnosed syphilis infection, order SYPHT / Syphilis Total Antibody with Reflex, Serum.

Specimen Required

Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 0.5 mL

Collection Instructions: Centrifuge and aliquot serum into plastic vial.

Useful For

Determining the current disease status and evaluating response to therapy for syphilis


This test should not be used as a primary diagnostic approach for syphilis.


This test is not useful for testing spinal fluid specimens.


This test is not intended for medical-legal use.


This assay provides a rapid plasma reagin (RPR) screen and can be used to monitor response to therapy in patients treated for syphilis infection.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
RRPRQ RPR Titer, S No No

Testing Algorithm

If this test is positive, then the titer will be performed at an additional charge.

Method Name

RPRRT: Multiplex Flow Immunoassay

RRPRQ: Flocculation/Agglutination

Reporting Name

RPR Screen, Response to Therapy, S

Specimen Type


Specimen Minimum Volume

0.4 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values


Day(s) Performed

Monday through Saturday

Report Available

Same day/1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

0065U (PLA Code)

86593-Rapid Plasma Reagin Titer (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
RPRRT RPR Screen, Response to Therapy, S 47236-5


Result ID Test Result Name Result LOINC Value
RPRRT RPR Screen, Response to Therapy, S 20507-0

NY State Approved



If not ordering electronically, complete, print, and send a Microbiology Test Request (T244) with the specimen.