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Test ID SAT24 Supersaturation Profile, 24 Hour, Urine

Useful For

Diagnosis and management of patients with renal lithiasis:

-In patients who have a radiopaque stone, for whom stone analysis is not available, the supersaturation data can be used to predict the likely composition of the stone. This may help in designing a treatment program

-Individual components of the supersaturation profile can identify specific risk factors for stones

-During follow-up, changes in the urine supersaturation can be used to monitor the effectiveness of therapy by confirming that the crystallization potential has indeed decreased

-Urine ammonium can be used to evaluate renal excretion of acid and urine pH

-The protein catabolic rate, calculated from the urine urea nitrogen, can be used to estimate a patient's protein intake

Profile Information

Test ID Reporting Name Available Separately Always Performed
SUPST Supersaturation, U No Yes
NAUP Sodium, U Yes, (order NAU) Yes
KUP Potassium, U Yes, (order KUR) Yes
CALCP Calcium, U Yes, (order CALU) Yes
MAGP Magnesium, U Yes, (order MAGU) Yes
CLUP Chloride, U Yes, (order CLU) Yes
POUP Phosphorus, U Yes, (order POU) Yes
SULFP Sulfate, U Yes, (order SULFU) Yes
CITP Citrate Excretion, U Yes, (order CITR) Yes
OXUP Oxalate, U Yes, (order OXU) Yes
UPHP pH, U Yes, (order PHU_) Yes
URCP Uric Acid, U Yes, (order URCU) Yes
CTUP Creatinine, U Yes, (order CTU) Yes
UOSMP Osmolality Yes, (order UOSMU) Yes
AMMP Ammonium, 24 Hr, U Yes, (order AMMO) Yes
UNP Urea Nitrogen, U No Yes
PCTR Protein Catabolic Rate, U No Yes

Method Name

CITP: Enzymatic

OXUP: Enzymatic using Oxalate Oxidase

USOMP: Freezing Point Depression

SULFP: High-Pressure Ion Chromatography (HPIC)

CALCP: Photometric, NM-BAPTA Reaction

MAGP: Colorimetric Endpoint Assay

POUP: Molybdic Acid

UPHP: pH Meter

NAUP, KUP, CLUP: Potentiometric, Indirect Ion-Selective Electrode (ISE)

CTUP: Enzymatic Colorimetric Assay

URCP: Uricase

AMMP: Enzymatic Assay

UNP: Kinetic UV Assay

Reporting Name

Supersaturation, U

Specimen Type

Urine


Necessary Information


1. 24-Hour volume is required.

2. Patient's height in centimeters and weight in kilograms are required if patient is less than 18 years old.



Specimen Required


Supplies: Diazolidinyl Urea (Germall) 5.0 mL (T822)

Container/Tube: Plastic, 60-mL urine bottle

Specimen Volume: 35 mL

Collection Instructions:

1. Collect urine for 24 hours.

2. Add 5 mL of diazolidinyl urea as preservative at start of collection, or refrigerate specimen during and after collection.

3. Specimen pH should be between 4.5 and 8 and will stay in this range if kept refrigerated. Specimens with pH >8 indicate bacterial contamination, and testing will be cancelled. Do not attempt to adjust pH as it will adversely affect results.

Additional Information: See Urine Preservatives-Collection and Transportation for 24-Hour Urine Specimens in Special Instructions for multiple collections.


Specimen Minimum Volume

25 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 14 days
  Frozen  14 days

Reference Values

SUPERSATURATION REFERENCE MEANS (Delta G: DG)

Calcium oxalate: 1.77 DG

Brushite: 0.21 DG

Hydroxyapatite: 3.96 DG

Uric acid: 1.04 DG

Sodium urate: 1.76 DG

 

INDIVIDUAL URINE ANALYTES

OSMOLALITY

0-11 months: 50-750 mOsm/kg

≥12 months: 150-1,150 mOsm/kg

 

pH

4.5-8.0

 

ALL REFERENCE RANGES BELOW ARE BASED ON 24-HOUR COLLECTIONS.

 

SODIUM

41-227 mmol/24 hours

Reference values have not been established for patients <16 years of age.

 

POTASSIUM

17-77 mmol/24 hours

Reference values have not been established for patients <16 years of age.

 

CALCIUM

Males: <250 mg/24 hours

Females: <200 mg/24 hours

Reference values have not been established for patients <18 years and >83 years of age

 

MAGNESIUM

51-269 mg/24 hours

Reference values have not been established for patients <18 years and >83 years of age

 

CHLORIDE

40-224 mmol/24 hours

Reference values have not been established for patients <16 years of age.

 

PHOSPHORUS

<1,100 mg/24 hours

 

SULFATE

7-47 mmol/24 hours

 

CITRATE EXCRETION

0-19 years: not established

20 years: 150-1,191 mg/24 hours

21 years: 157-1,191 mg/24 hours

22 years: 164-1,191 mg/24 hours

23 years: 171-1,191 mg/24 hours

24 years: 178-1,191 mg/24 hours

25 years: 186-1,191 mg/24 hours

26 years: 193-1,191 mg/24 hours

27 years: 200-1,191 mg/24 hours

28 years: 207-1,191 mg/24 hours

29 years: 214-1,191 mg/24 hours

30 years: 221-1,191 mg/24 hours

31 years: 228-1,191 mg/24 hours

32 years: 235-1,191 mg/24 hours

33 years: 242-1,191 mg/24 hours

34 years: 250-1,191 mg/24 hours

35 years: 257-1,191 mg/24 hours

36 years: 264-1,191 mg/24 hours

37 years: 271-1,191 mg/24 hours

38 years: 278-1,191 mg/24 hours

39 years: 285-1,191 mg/24 hours

40 years: 292-1,191 mg/24 hours

41 years: 299-1,191 mg/24 hours

42 years: 306-1,191 mg/24 hours

43 years: 314-1,191 mg/24 hours

44 years: 321-1,191 mg/24 hours

45 years: 328-1,191 mg/24 hours

46 years: 335-1,191 mg/24 hours

47 years: 342-1,191 mg/24 hours

48 years: 349-1,191 mg/24 hours

49 years: 356-1,191 mg/24 hours

50 years: 363-1,191 mg/24 hours

51 years: 370-1,191 mg/24 hours

52 years: 378-1,191 mg/24 hours

53 years: 385-1,191 mg/24 hours

54 years: 392-1,191 mg/24 hours

55 years: 399-1,191 mg/24 hours

56 years: 406-1,191 mg/24 hours

57 years: 413-1,191 mg/24 hours

58 years: 420-1,191 mg/24 hours

59 years: 427-1,191 mg/24 hours

60 years: 434-1,191 mg/24 hours

>60 years: not established

 

OXALATE

0.11-0.46 mmol/24 hours

 

URIC ACID

Diet-dependent: <750 mg/24 hours

 

CREATININE

Normal values mg per 24 hours:

Males: 955-2936 mg/24 hours

Females: 601-1689 mg/24 hours

Reference ranges for male and female patients <18 and >83 years of age have not been established.

 

The expected urine creatinine excretion per 24 hours:

Males: 13-29 mg/kg of body weight/24 hours

Females: 9-26 mg/kg of body weight/24 hours

 

Reference ranges for male and female patients <18 and >83 years of age have not been established.

Note: To convert to mg/kg of body weight/24 hours, divide the mg/24 hours result by body weight in kg.

 

AMMONIUM

15-56 mmol/24 hour

Reference values have not been established for patients <18 years and >77 years of age.

 

UREA NITROGEN

5.0-16.0 g/24 hours

 

PROTEIN CATABOLIC RATE

56-125 g/24 hours

Day(s) and Time(s) Performed

Monday through Friday; 8 a.m.-4 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information

82340-Calcium

82436-Chloride

82507-Citrate excretion

82570-Creatinine

83735-Magnesium

83935-Osmolality

83945-Oxalate

83986-pH

84105-Phosphorus

84133-Potassium

84300-Sodium

84392-Sulfate

84560-Uric acid

82140-Ammonium

84540-Urea Nitrogen

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SAT24 Supersaturation, U 81232-1

 

Result ID Test Result Name Result LOINC Value
CAL24 Calcium, 24 Hr, U 6874-2
UN24 Urea Nitrogen, U 3096-5
MAG24 Magnesium, 24 Hr, U 24447-5
PCTR Protein Catabolic Rate, U 93746-6
AMM24 Ammonium, 24 Hr, U 25308-8
UPHU pH, U 27378-9
URACI Uric Acid, U 3087-4
UOSMP Osmolality 2694-8
CITRE Citrate Excretion, U 6687-8
CL24 Chloride, U 2079-2
CRETU Creatinine, U 2162-6
K24U Potassium, U 2829-0
NA24 Sodium, U 2956-1
OXLT Oxalate, U (mmol/24 h) 14862-7
PHS_U Phosphorus, U 2779-7
SULF_ Sulfate Urine 26889-6
21041 Calcium Oxalate Crystal 81623-1
21042 Brushite Crystal 42673-4
OXU2 Oxalate, mg/24 h 2701-1
21043 Hydroxyapatite Crystal 81622-3
21044 Uric Acid Crystal 42678-3
21045 Sodium Urate Crystal 43423-3
CLDUR Collection Duration 13362-9
VL38 Volume 3167-4
21060 Interpretation 59462-2

NY State Approved

Yes

Urine Preservative Collection Options

Note: The addition of preservative or application of temperature controls must occur within 4 hours of completion of the collection.

Ambient

No

Refrigerate

Yes

Frozen

Yes

50% Acetic Acid

No

Boric Acid

No

Diazolidinyl Urea

Preferred

6M Hydrochloric Acid

No

6M Nitric Acid

No

Sodium Carbonate

No

Thymol

No

Toluene

No

Forms

If not ordering electronically, complete, print, and send a Renal Diagnostics Test Request (T830) with the specimen.