Sign in →

Test ID SGSS Synthetic Glucocorticoid Screen, Serum

Useful For

Confirming the presence of listed synthetic glucocorticoids (see Interpretation)


Confirming the cause of secondary adrenal insufficiency

Method Name

Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS) Stable Isotope Dilution Analysis

Reporting Name

Synthetic Glucocorticoid Screen, S

Specimen Type


Specimen Required

Collection Container/Tube: 

Preferred: Red top

Acceptable: Serum gel

Submission Container/Tube: Plastic vial

Specimen Volume: 2 mL

Specimen Minimum Volume

1.1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen (preferred) 14 days
  Refrigerated  7 days
  Ambient  24 hours

Reference Values


Cutoff concentrations

Betamethasone: 0.10 mcg/dL

Budesonide: 0.20 mcg/dL

Dexamethasone: 0.10 mcg/dL

Fludrocortisone: 0.10 mcg/dL

Flunisolide: 0.10 mcg/dL

Fluorometholone: 0.10 mcg/dL

Megestrol acetate: 0.10 mcg/dL

Methylprednisolone: 0.10 mcg/dL

Prednisolone: 0.10 mcg/dL

Prednisone: 0.10 mcg/dL

Triamcinolone: 0.30 mcg/dL

Triamcinolone acetonide: 0.10 mcg/dL


Values for normal patients not taking these synthetic glucocorticoids should be less than the cutoff concentration (detection limit).

Day(s) and Time(s) Performed

Tuesday, Thursday; 9 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
SGSS Synthetic Glucocorticoid Screen, S 43141-1


Result ID Test Result Name Result LOINC Value
23593 Betamethasone 41745-1
23594 Budesonide 41747-7
23595 Dexamethasone 14062-4
23596 Fludrocortisone 41754-3
23597 Flunisolide 41755-0
23598 Fluorometholone 41756-8
23599 Fluticasone Propionate 41757-6
23600 Megestrol Acetate 41762-6
23601 Methylprednisolone 14186-1
23602 Prednisolone 12727-4
23603 Prednisone 12434-7
23604 Triamcinolone 41766-7
23605 Triamcinolone Acetonide 41767-5

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

NY State Approved