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HelpTest ID SMOGA Monoclonal Gammopathy Screen, Serum
Advisory Information
To monitor a patient with an established diagnosis of a monoclonal gammopathy, order MMOGA / Monoclonal Gammopathy Monitoring, Serum.
Specimen Required
Patient Preparation: Fasting (12 hour) preferred but not required
Container/Tube:
Preferred: Serum gel
Acceptable: Red top
Specimen Volume: 2 mL
Useful For
Screening and diagnosis of monoclonal gammopathies including analysis of free light chains
Assessing the risk of progression from monoclonal gammopathy of undetermined significance to multiple myeloma
Profile Information
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| TPE | Total Protein | Yes, (Order TP) | Yes |
| SPE | Protein Electrophoresis | No | Yes |
| MPTS | M-protein Isotype MALDI-TOF MS, S | Yes, (Order MALDO) | Yes |
| KFLC | Kappa Free Light Chain, S | Yes, (Order FLCP) | Yes |
| LFLC | Lambda Free Light Chain, S | Yes, (Order FLCP) | Yes |
| KLR | Kappa/Lambda FLC Ratio | Yes, (Order FLCP) | Yes |
Reflex Tests
| Test ID | Reporting Name | Available Separately | Always Performed |
|---|---|---|---|
| IMFX | Immunofixation | Yes, (Order IMFXO) | No |
Testing Algorithm
This test includes total protein, serum protein electrophoresis, heavy and light chain typing (kappa and lambda), and quantitation of kappa and lambda free light chains.
If a light chain is identified without a corresponding heavy chain during initial testing, immunofixation with IgD and IgE antisera will be performed at an additional charge.
See Laboratory Screening Tests for Suspected Multiple Myeloma in Special Instructions.
Method Name
TPE: Biuret
SPE: Agarose Gel Electrophoresis
MPTS: Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS)
KFLC, LFLC, KLR: Nephelometry
Reporting Name
Monoclonal Gammopathy Screen, SSpecimen Type
SerumSpecimen Minimum Volume
1.5 mL
Specimen Stability Information
| Specimen Type | Temperature | Time |
|---|---|---|
| Serum | Refrigerated (preferred) | 14 days |
| Frozen | 14 days | |
| Ambient | 72 hours |
Reference Values
TOTAL PROTEIN:
≥1 year: 6.3-7.9 g/dL
Reference values have not been established for patients that are <12 months of age.
PROTEIN ELECTROPHORESIS
Albumin: 3.4-4.7 g/dL
Alpha-1-globulin: 0.1-0.3 g/dL
Alpha-2-globulin: 0.6-1.0 g/dL
Beta-globulin: 0.7-1.2 g/dL
Gamma-globulin: 0.6-1.6 g/dL
An interpretive comment is provided with the report.
Reference values have not been established for patients that are <16 years of age.
M-PROTEIN ISOTYPE MALDI-TOF MS
No monoclonal protein detected
KAPPA-FREE LIGHT CHAIN
0.33-1.94 mg/dL
LAMBDA-FREE LIGHT CHAIN
0.57-2.63 mg/dL
KAPPA/LAMBDA-FREE LIGHT-CHAIN RATIO
0.26-1.65
Day(s) and Time(s) Performed
Monday through Saturday; 2 p.m.
Performing Laboratory
Mayo Clinic Laboratories in Rochester
Test Classification
See Individual Test IDsCPT Code Information
83883 x 2
84155
84165
0077U
86334 (if appropriate)
LOINC Code Information
| Test ID | Test Order Name | Order LOINC Value |
|---|---|---|
| SMOGA | Monoclonal Gammopathy Screen, S | 90992-9 |
| Result ID | Test Result Name | Result LOINC Value |
|---|---|---|
| KFLC | Kappa Free Light Chain, S | 36916-5 |
| KLR | Kappa/Lambda FLC Ratio | 48378-4 |
| LFLC | Lambda Free Light Chain, S | 33944-0 |
| TPE | Total Protein | 2885-2 |
| 602837 | Albumin | 2862-1 |
| 65198 | M-protein Isotype MALDI-TOF MS | 90990-3 |
| 602838 | Alpha-1 Globulin | 2865-4 |
| 602839 | Alpha-2 Globulin | 2868-8 |
| 602840 | Beta-Globulin | 2871-2 |
| 602841 | Gamma-Globulin | 2874-6 |
| 602842 | A/G Ratio | 44429-9 |
| 602843 | M spike | 51435-6 |
| 602844 | M spike | 35559-4 |
| 602836 | Impression | 49296-7 |