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Test ID SMOGA Monoclonal Gammopathy Screen, Serum


Advisory Information


To monitor a patient with an established diagnosis of a monoclonal gammopathy, order MMOGA / Monoclonal Gammopathy Monitoring, Serum.



Specimen Required


Patient Preparation: Fasting (12 hour) preferred but not required

Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Specimen Volume: 2 mL


Useful For

Screening and diagnosis of monoclonal gammopathies including analysis of free light chains

 

Assessing the risk of progression from monoclonal gammopathy of undetermined significance to multiple myeloma

Profile Information

Test ID Reporting Name Available Separately Always Performed
TPE Total Protein Yes, (Order TP) Yes
SPE Protein Electrophoresis No Yes
MPTS M-protein Isotype MALDI-TOF MS, S Yes, (Order MALDO) Yes
KFLC Kappa Free Light Chain, S Yes, (Order FLCP) Yes
LFLC Lambda Free Light Chain, S Yes, (Order FLCP) Yes
KLR Kappa/Lambda FLC Ratio Yes, (Order FLCP) Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
IMFX Immunofixation Yes, (Order IMFXO) No

Testing Algorithm

This test includes total protein, serum protein electrophoresis, heavy and light chain typing (kappa and lambda), and quantitation of kappa and lambda free light chains.

 

If a light chain is identified without a corresponding heavy chain during initial testing, immunofixation with IgD and IgE antisera will be performed at an additional charge.

 

See Laboratory Screening Tests for Suspected Multiple Myeloma in Special Instructions.

Method Name

TPE: Biuret

SPE: Agarose Gel Electrophoresis

MPTS: Matrix-Assisted Laser Desorption/Ionization-Time of Flight Mass Spectrometry (MALDI-TOF MS)

KFLC, LFLC, KLR: Nephelometry

Reporting Name

Monoclonal Gammopathy Screen, S

Specimen Type

Serum

Specimen Minimum Volume

1.5 mL

Specimen Stability Information

Specimen Type Temperature Time
Serum Refrigerated (preferred) 14 days
  Frozen  14 days
  Ambient  72 hours

Reference Values

TOTAL PROTEIN:

≥1 year: 6.3-7.9 g/dL

Reference values have not been established for patients that are <12 months of age.

 

PROTEIN ELECTROPHORESIS

Albumin: 3.4-4.7 g/dL

Alpha-1-globulin: 0.1-0.3 g/dL

Alpha-2-globulin: 0.6-1.0 g/dL

Beta-globulin: 0.7-1.2 g/dL

Gamma-globulin: 0.6-1.6 g/dL

An interpretive comment is provided with the report.

Reference values have not been established for patients that are <16 years of age.

 

M-PROTEIN ISOTYPE MALDI-TOF MS

No monoclonal protein detected

 

KAPPA-FREE LIGHT CHAIN

0.33-1.94 mg/dL

 

LAMBDA-FREE LIGHT CHAIN

0.57-2.63 mg/dL

 

KAPPA/LAMBDA-FREE LIGHT-CHAIN RATIO

0.26-1.65

Day(s) and Time(s) Performed

Monday through Saturday; 2 p.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

See Individual Test IDs

CPT Code Information

83883 x 2

84155

84165

0077U

86334 (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SMOGA Monoclonal Gammopathy Screen, S 90992-9

 

Result ID Test Result Name Result LOINC Value
KFLC Kappa Free Light Chain, S 36916-5
KLR Kappa/Lambda FLC Ratio 48378-4
LFLC Lambda Free Light Chain, S 33944-0
TPE Total Protein 2885-2
602837 Albumin 2862-1
65198 M-protein Isotype MALDI-TOF MS 90990-3
602838 Alpha-1 Globulin 2865-4
602839 Alpha-2 Globulin 2868-8
602840 Beta-Globulin 2871-2
602841 Gamma-Globulin 2874-6
602842 A/G Ratio 44429-9
602843 M spike 51435-6
602844 M spike 35559-4
602836 Impression 49296-7

NY State Approved

Yes