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Test ID SPAS Arsenic Speciation, Random, Urine

Specimen Required

Patient Preparation:

1. Patient should not eat seafood for a 48-hour period prior to start of collection.

2. High concentrations of gadolinium and iodine are known to interfere with most metals tests. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for at least 96 hours.


-Urine Tubes, 10 mL (T068)

-Aliquot Tube, 5 mL (T465)

Collection Container/Tube: Clean, plastic urine collection container

Submission Container/Tube: Plastic vial or a clean, plastic aliquot container with no metal cap or glued insert

Specimen Volume: 5 mL

Collection Instructions:

1. Collect a random urine specimen.

2. See Trace Metals Analysis Specimen Collection and Transport in Special Instructions for complete instructions.

Useful For

Diagnosis of arsenic intoxication in random urine specimens

Testing Algorithm

Total arsenic will be performed first. If the total arsenic concentration is 10 mcg/L or greater, then speciation will be performed and reported.


If total arsenic is below 10 mcg/L, total arsenic will be reported as less than 10 mcg/L and speciation will not be performed.

Method Name

Ion Chromatography Inductively Coupled Plasma-Mass Spectrometry (ICP-MS)

Reporting Name

Arsenic Speciation, Random, U

Specimen Type


Specimen Minimum Volume

3 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Urine Refrigerated (preferred) 28 days
  Frozen  28 days
  Ambient  72 hours

Reference Values


<35 mcg/L

Reference values apply to all ages.


Arsenic Speciation Interpretive Information:

The toxic arsenic concentration represents the sum of the inorganic and methylated arsenic species. The reference value for toxic arsenic is <35 mcg/L. This value is based on the ACGIH Biological Exposure Index (BEI), which does not include the nontoxic organic arsenic.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.

CPT Code Information


LOINC Code Information

Test ID Test Order Name Order LOINC Value
SPAS Arsenic Speciation, Random, U 54454-4


Result ID Test Result Name Result LOINC Value
607692 Inorganic Arsenic (Toxic) 12481-8
607693 Methylated Arsenic (Toxic) 53779-5
607694 Organic Arsenic (Non-Toxic) 53778-7
609405 Toxic Arsenic Concentration 96250-6
607691 Total Arsenic Concentration 5586-3

NY State Approved


Day(s) Performed

Monday through Friday

Report Available

2 to 4 days