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Test ID SYPH1 Syphilis IgG with Reflex, Enzyme Immunoassay, Serum


Specimen Required


Collection Container/Tube:

Preferred: Serum gel

Acceptable: Red top

Submission Container/Tube: Plastic vial

Specimen Volume: 1.5 mL

Collection Instructions: Centrifuge and aliquot serum into a plastic vial.


Useful For

Aid for the diagnosis of infection with Treponema pallidum using an algorithmic approach

 

Routine prenatal screening

 

This test is not offered as a screening or confirmatory test for blood donor specimens.

 

This test is not useful for diagnosis of congenital syphilis.

Highlights

This testing should be used to assess for infection with Treponema pallidum or for routine prenatal screening.

 

Syphilis screening at Mayo Clinic and Mayo Clinic Laboratories is performed using the reverse screening algorithm.

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
RRPRS RPR Screen w/ Reflex to Titer, S No No
RTPPA Syphilis Ab, TP-PA, S Yes, (Order TPPA) No
RRPRQ RPR Titer, S No No

Testing Algorithm

If the syphilis IgG result is reactive or equivocal, then the rapid plasma reagin (RPR) screen will be performed at an additional charge.

 

If the RPR screen is positive, then the RPR titer will be performed at an additional charge.

 

If the RPR screen is negative, then syphilis antibody Treponema pallidum particle agglutination testing will be performed at an additional charge.

 

See Syphilis Serology Algorithm

Special Instructions

Method Name

SYPH1: Enzyme Immunoassay (EIA)

RRPRS, RRPRQ: Flocculation/Agglutination

RTPPA: Particle Agglutination

Reporting Name

Syphilis IgG w/ Reflex, EIA, S

Specimen Type

Serum

Specimen Minimum Volume

1 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Frozen 14 days

Reference Values

SYPHILIS IgG SCREEN

Nonreactive

 

RAPID PLASMA REAGIN SCREEN

Negative

 

RAPID PLASMA REAGIN TITER

Negative

 

SYPHILIS ANTIBODY, Treponema pallidum-PARTICLE AGGLUTINATION

Negative

 

Reference values apply to all ages

Day(s) Performed

Monday through Friday, Sunday

Report Available

Same day/1 to 4 days

Performing Laboratory

Mayo Clinic Laboratories in Rochester

Test Classification

This test has been cleared, approved, or is exempt by the US Food and Drug Administration and is used per manufacturer's instructions. Performance characteristics were verified by Mayo Clinic in a manner consistent with CLIA requirements.

CPT Code Information

86780-Syphilis IgG Screen

86592-Syphilis Rapid Plasma Reagin Screen (if appropriate)

86593-Rapid Plasma Reagin Titer (if appropriate)

86780-Syphilis Antibody by TP-PA (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
SYPH1 Syphilis IgG w/ Reflex, EIA, S 47238-1

 

Result ID Test Result Name Result LOINC Value
SYPH1 Syphilis IgG w/ Reflex, EIA, S 47238-1

NY State Approved

Yes

Forms

If not ordering electronically, complete, print, and send Infectious Disease Serology Test Request (T916) with the specimen.